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Fig. 5 | Cancer Cell International

Fig. 5

From: Nanos3, a cancer-germline gene, promotes cell proliferation, migration, chemoresistance, and invasion of human glioblastoma

Fig. 5

Nanos3 inhibits the formation of glioblastoma via inhibiting the stemness of glioblastoma cells. a The tumor growth sizes were recorded every 6 days between Nanos3 WT and Nanos3+/− GBM cell lines in xenograft tumor models; b Tumor growth was observed from GBM cells with Nanos3 alterations that were implanted subcutaneously in nude mice. n = 5; data are shown as the mean ± SE. ***P < 0.001. c Western blot analysis of the relative protein levels of CD133, Oct4, Ki67, Dazl, BMP4, and GFAP in Nanos3+/− and WT GBM cells. d Quantitative analysis of the relative protein levels of CD133, Oct4, Ki67 and BMP4 in GBM cells was carried out in triplicate. Data are shown as the mean ± SE. *P < 0.05, **P < 0.01, ***P < 0.001

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