Table 2 Concordance between whole sections and paired TMAs of PD-L1 expression
TMAs | Whole sections | Agreement rate (95% CI) | Cohen’s κ value | ||
|---|---|---|---|---|---|
No. of cores | Positive | Negative | Total | ||
1 | |||||
 Positive | 54 | 2 | 56 | 60.4% (52.5–68.3%) | 0.294 (0.188–0.400) |
 Negative | 57 | 36 | 93 | ||
 Total | 111 | 38 | 149 | ||
2 | |||||
 Positive | 71 | 2 | 73 | 72.3% (65.0–79.6%) | 0.450 (0.327–0.573) |
 Negative | 39 | 36 | 75 | ||
 Total | 110 | 38 | 148 | ||
3 | |||||
 Positive | 85 | 2 | 87 | 82.2% (75.9–85.5%) | 0.607 (0.478–0.736) |
 Negative | 24 | 35 | 59 | ||
 Total | 109 | 37 | 146 | ||
4 | |||||
 Positive | 86 | 3 | 89 | 85.7% (79.8–91.6%) | 0.672 (0.543–0.801) |
 Negative | 17 | 34 | 51 | ||
 Total | 103 | 37 | 140 | ||
5 | |||||
 Positive | 87 | 3 | 90 | 92.4% (87.8–97.0%) | 0.818 (0.710–0.926) |
 Negative | 7 | 34 | 41 | ||
 Total | 94 | 37 | 131 | ||
6 | |||||
 Positive | 85 | 4 | 89 | 95.2% (91.3–99.0%) | 0.883 (0.790–0.975) |
 Negative | 2 | 33 | 35 | ||
 Total | 87 | 37 | 124 | ||