Fig. 1

Forced miR-223 expression enhanced the cisplatin resistance of NSCLC cells. a Expression of miR-223 in NSCLC cell lines were detected by qRT-PCR. U6 was used as the internal reference. b Cell viability of NSCLC cell lines treated with different concentrations of cisplatin with a CCK-8 assay and IC50 value was calculated. c Expression of miR-223 in NSCLC cell lines were detected by qRT-PCR after cisplatin treatment. **P < 0.01; ***P < 0.001 compared with the control. d, e NSCLC cells were transfected with an miR-223 mimic, miR-223 inhibitor, or the scrambled control. After 48 h post-transfection, different concentrations of cisplatin were added and cell viability was determined with a CCK-8 assay after 24 h. **P < 0.01 vs. the control. f Real-time PCR was used to validate the efficiency of the miR-223 inhibitor or miR-223 mimic. **P < 0.01; ***P < 0.001 compared with the control