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Fig. 2 | Cancer Cell International

Fig. 2

From: MiR-223 regulates autophagy associated with cisplatin resistance by targeting FBXW7 in human non-small cell lung cancer

Fig. 2

MiR-223 overexpression promoted autophagy in NSCLC cells. a, b Autophagy flux was examined in A549 and NCI-H1299 cells transfected with the miR-223 mimics or miR-control using a tandem adenovirus RFP-GFP-LC3 construct. The number of autophagosomes (yellow dots) and autolysosomes (red-only dots) were assessed. *P < 0.05 compared with Negative control. c, d Autophagy flux was examined in A549 and NCI-H1299 cells transfected with the miR-223 mimics or miR-control following treatment with the IC50 of cisplatin. The number of autophagosomes (yellow dots) and autolysosomes (red-only dots) were assessed. *P < 0.05; **P < 0.01 compared with Negative control + cisplatin

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