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Fig. 3 | Cancer Cell International

Fig. 3

From: MiR-223 regulates autophagy associated with cisplatin resistance by targeting FBXW7 in human non-small cell lung cancer

Fig. 3

Blocking autophagy reversed miR-223-mediated cisplatin resistance. a Cell viability of A549 and NCI-H1299 cells cultured in different concentrations of cisplatin following 10 μM chloroquine and transfection with either the miR-223 mimics or miR-control. b Cell viability of A549 and NCI-H1299 cells cultured in different concentrations of cisplatin following treatment with 100 nM rapamycin and transfection with either the miR-223 mimics or miR-control. c, d Cellular proliferation of A549 and NCI-H1299 cells cultured in the IC50 of cisplatin following treatment with 10 μM chloroquine or the control component and transfection with the miR-223 mimics or miR-control transfection detected using an EdU assay. e, f Cellular proliferation of A549 and NCI-H1299 cells cultured in the IC50 of cisplatin following 100 nM rapamycin or the control component and transfected with either the miR-223 mimics or miR-control detected using an EdU assay. Photomicrographs and bar graphs depicted the EdU staining and relative EdU-positive ratio, respectively

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