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Fig. 6 | Cancer Cell International

Fig. 6

From: MiR-223 regulates autophagy associated with cisplatin resistance by targeting FBXW7 in human non-small cell lung cancer

Fig. 6

miR-223 induced cisplatin resistance by suppressing FBXW7. a Cell viability of A549 and NCI-H1299 cells cultured in different concentrations of cisplatin following treatment with the miR-223 inhibitor plus transfection with FBXW7 siRNA or FBXW7 siRNA alone. *P < 0.05; **P < 0.01 vs. control. b Real-time PCR was used to validate the efficiency of the miR-223 inhibitor or FBXW7 siRNA. c, d Western blot of FBXW7, LC3-I/II, and SQSTM1 in NSCLC cells treated with the miR-223 inhibitor plus transfection with FBXW7 siRNA, FBXW7 siRNA alone, or the scrambled control. *P < 0.05; **P < 0.01 vs. NC

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