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Fig. 1 | Cancer Cell International

Fig. 1

From: Circular RNA circ-CSPP1 regulates CCNE2 to facilitate hepatocellular carcinoma cell growth via sponging miR-577

Fig. 1

Circ-CSPP1was upregulated in HCC tissues and cells and associated with poor prognosis. a The intersections of differentially expressed circRNAs among GSE97332, GSE78520 and GSE94508 databases were determined by Venn analysis. Circ-CSPP1 was highly expressed in tumor (T) as compared to adjacent normal tissues (N) in GSE78520 (b), GSE97332 (c) and GSE94508 (d) databases. e The expression level of circ-CSPP1 in 72 human HCC tissues (HCC) and adjacent non-tumor tissues (Normal) was analyzed by qRT-PCR. f ISH assay showed consistent results as e. Magnifications, ×100 and ×200. g The relationship between circ-CSPP1 expression and prognosis of HCC patients was also investigated by Kaplan–Meier survival analysis. hThe mRNA expression of circ-CSPP1 in HCC cell lines and human liver cell line LO2 was analyzed by qRT-PCR. i RNase R digestion was conducted to verify the circular characteristics of circ-CSPP1. *p < 0.05; **p < 0.01 and ***p < 0.001

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