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Fig. 3 | Cancer Cell International

Fig. 3

From: Upregulation of ARHGAP30 attenuates pancreatic cancer progression by inactivating the β-catenin pathway

Fig. 3

ARHGAP30 overexpression suppressed pancreatic cancer cell proliferation, migration, and invasion and promoted apoptosis. ARHGAP30 was overexpressed in ASPC1 cells. a Cell proliferation at 0, 12, 24 and 48 h was evaluated using the CCK-8 assay. b, c Cell migration and invasion were measured using a transwell assay at 72 h. d Cell apoptosis was assessed using flow cytometry at 48 h. e The levels of the related proteins β-catenin, Bcl-2, Bax, cleaved caspase-3, MMP2, and MMP9 were analyzed using western blotting. f The mRNA expression of β-catenin, Bcl-2 and MMP2 was detected. *p < 0.05, **p < 0.01, ***p < 0.001 vs. vector

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