Fig. 4

ARHGAP30 knockdown likely contributed to pancreatic cancer progression by activating the β-catenin pathway and modulating related genes. SW1990 cells were treated with the shARHGAP30 lentivirus and the β-catenin inhibitor XAV939. a Cell proliferation was evaluated using CCK-8 assay at 0, 12, 24, and 48 h. b, c Cell migration and invasion were measured using a transwell assay at 72 h. d Cell apoptosis was assessed using flow cytometry at 48 h. e The levels of the related proteins β-catenin, Bcl-2, Bax, cleaved caspase-3, MMP2, and MMP9 were analyzed using western blotting. **p < 0.01, ***p < 0.001 vs. vehicle + vector, ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. vehicle + shARHGAP30