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Fig. 1 | Cancer Cell International

Fig. 1

From: HMGB1 mediates lipopolysaccharide-induced inflammation via interacting with GPX4 in colon cancer cells

Fig. 1

LPS increases inflammation in HMGB1-dependent manner. a Quantitative real-time PCR results showed that LPS elevated the mRNA levels of pro-inflammatory cytokines IL1β, IL6 and TNFα after LPS treatment for 48 h in SW480 and HCT116 cells. b Western blot results indicated LPS increased the HMGB1, p-IKBα and p-p65 proteins expression in SW480 and HCT116 cells, when siHMGB1 were introduced, this effect was weakened. c qRT-PCR results revealed that siHMGB1 effectively decreased the IL1β, IL6 and TNFα mRNA levels increased by LPS. d Extracellular HMGB1 were detected and the results showed no significant change of HMGB1 were observed in extracellular space after LPS treatment for 0 h to 72 h

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Cancer Cell International

ISSN: 1475-2867

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