Fig. 1

SNHG16 is up-regulated and miR-338-3p is down-regulated in cisplatin resistant neuroblastoma tissues and cells. a, b The expression of SNHG16 and miR-338-3p was detected using qRT-PCR in cisplatin resistant and sensitive neuroblastoma tumor tissue. c, d The IC50 value for cisplatin was calculated by CCK-8 assay in SK-N-AS-R and SK-N-SH-R cells. e Western blot analysis of the levels of MRP1 and p-gp protein in cisplatin-resistant neuroblastoma cell lines SK-N-AS-R and SK-N-SH-R and parental SK-N-AS and SK-N-SH was performed. f, g The expression of SNHG16 and miR-338-3p was detected using qRT-PCR in cisplatin-resistant neuroblastoma cell lines (SK-N-AS-R and SK-N-SH-R) and corresponding parental neuroblastoma cell lines (SK-N-AS and SK-N-SH). The same experiment was repeated three times, and the average was taken. *P < 0.05