Fig. 2

SNHG16 deletion inhibits cell cisplatin resistance and malignant phenotypes in neuroblastoma. SNHG16 was silenced in SK-N-AS-R and SK-N-SH-R cells using siRNA sequences targeting SNHG16. a The relative expression of SNHG16 was measured using qRT-PCR. b The IC50 value for cisplatin was assessed by CCK-8 assay. c The expressions of drug-resistance associated proteins MRP1 and P-gp were examined by western blot assay. d The CCK-8 assay was performed to detect cell proliferation. e, f Transwell assay was used to determine cell migration and invasion ability. g Cell apoptosis was analyzed using Flow cytometric analysis. The same experiment was repeated three times, and data represented as the average of three independent replicates. *P < 0.05