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Fig. 1 | Cancer Cell International

Fig. 1

From: Matrine inhibits cell growth, migration, invasion and promotes autophagy in hepatocellular carcinoma by regulation of circ_0027345/miR-345-5p/HOXD3 axis

Fig. 1

Matrine inhibited growth, metastasis and activated autophagy of HCC cells in vitro. After Huh-7 and HCCLM3 cells were exposed to various concentrations of matrine for 48 h. a, b Cell viability was determined by CCK-8 assay. c Cell apoptosis rate was analyzed by Flow cytometry. d, e Western blot assay was used to detect the expression of apoptosis-related proteins Bcl-2, Bax and cleaved-caspase 9. f, g Cell cycle was determined by Flow cytometry. h, i Cell migration and invasion were estimated by Transwell assay. j, k Western blot assay was employed to measure the levels of autophagy-related proteins LC3-II, LC3-I and Beclin 1. *P < 0.05

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Cancer Cell International

ISSN: 1475-2867

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