Fig. 7

Matrine inhibited the tumor growth of HCC in vivo. HCCLM3 cells were inoculated into nude mice and divided into two groups (n = 5 each group), one treated with matrine and the other treated with saline to act as control. a, b Volume and weight of the tumors were measured. c–e Abundances of circ_0027345, miR-345-5p and HOXD3 in that tumor tissues were examined by qRT-PCR. f The protein expression of HOXD3 was determined by western blot. *P < 0.05