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Fig. 7 | Cancer Cell International

Fig. 7

From: GSK-J4 induces cell cycle arrest and apoptosis via ER stress and the synergism between GSK-J4 and decitabine in acute myeloid leukemia KG-1a cells

Fig. 7

GSK-J4 exerts a synergistic effect with decitabine in KG-1a cells. a Cell viability was analyzed using the CCK-8 assay kit to detect the effect of decitabine on KG-1a cell proliferation. b Cell viability was also detected with CCK-8 assay kit to evaluate the combination effect of decitabine and GSK-J4 on KG-1a cell growth. c Following exposure to GSK-J4 and decitabine, the ratio of apoptotic cells was analyzed using flow cytometry. d Statistical analysis of the apoptotic rate.Values represent the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01. e The expression levels of bax and cle-caspase-9 in KG-1a cells exposed to decitabine and GSK-J4 were detected by Western blotting. f, g Statistical analysis of the expression levels of Bax and cle-caspase-9. β-Actin was used as an internal control. Values represent the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01

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