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Table 2 Representative circular RNAs targeting angiogenesis

From: Circular RNA and tumor microenvironment

CircRNA

Expression 

Targeted miRNA

Downstream target

Cancer type

Functions

Clinical correlation

Reference

circPIP5K1A

Up-Regulated

MiR-600

HIF-1α

Non-Small Cell Lung Cancer

Promoting angiogenesis by regulating VEGFR

/

[108]

circSCAF11

Up-Regulated

MiR-421

VEGFA

Glioma

Promoting angiogenesis by regulating VEGFR

Overall survival

[115]

Circ0001429

Up-Regulated

MiR-205-5P

VEGFA

Bladder Cancer

Promoting angiogenesis by regulating VEGFR

Overall survival

[116]

circular RNA MYLK

Up-Regulated

MiR-29A

VEGFA

Bladder Cancer

Promoting angiogenesis by regulating VEGFR

TNM stage, pathological grade

[114]

circ_002136

Up-Regulated

MiR-138-5P

SOX13

Glioma

Promoting angiogenesis by regulating SOX13

/

[118]

circ-SHKBP1

Up-Regulated

MiR-544A/Mir-379

FOXP1/FOXP2

Glioma

Promoting angiogenesis ability of endothelial cell by regulating FOXP1/FOXP2

/

[119]

circ-IARS

Up-Regulated

MiR-122

RhoA

Pancreatic Cancer

Increasing endothelial monolayer permeability to promote cancer development

Vascular invasion, TNM stage, liver metastasis, postoperative survival time

[120]