Fig. 1
From: Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
The role and underlying molecular mechanisms of SNHG6 in multiple human cancers. SNHG6 could get involved in the progress of cell migration and invasion, cell metastasis, cell cycle, cell progression, EMT, autophagy and genome-wide hypomethyltion, mainly via the following mechanisms: (i) SNHG6 functions as miRNA sponges to antagonize the connections between multiple tumor suppressor miRNAs and their target mRNAs. (ii) SNHG6 acts as a scaffold RNA molecule by interacting with EZH2, a subunit of the polycomb repressive complex to influence the expression of downstream effectors of EZH2. (iii) SNHG6 activates JNK pathway, PI3K/AKT/mTOR and TGFβ/SMAD pathway