Skip to main content
Fig. 6 | Cancer Cell International

Fig. 6

From: ZKSCAN3 drives tumor metastasis via integrin β4/FAK/AKT mediated epithelial–mesenchymal transition in hepatocellular carcinoma

Fig. 6

ITGB4 activates AKT phosphorylation by FAK rather than SRC. a Phosphorylation of FAK and Src induced by ITGB4 alteration. b FAK inhibitors decreased AKT phosphorylation. Western blot results revealed that AKT phosphorylation level decreased significantly in ITGB4-overexpressing cells treated with FAK inhibitor PF573228 (10 μM). Src inhibitor Dasatinib (10 μM) had no effect on AKT phosphorylation. *P < 0.05. c, d FAK inhibitor PF573228 was used in ITGB4-overexpressing cells. Transwell assay for migration and invasion (c) and western blot (d) for EMT markers were performed. *P < 0.05

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us