Fig. 2

Circ_0000284 expression was aberrantly increased in NSCLC and this up-regulation was associated with the low survival in NSCLC patients. a, b Circ_0000284 (a) and HIPK3 mRNA (b) levels were detected via qRT-PCR in NSCLC and normal tissues. c, d The qRT-PCR was conducted for circ_0000284 expression analysis in NSCLC tissues of I + II and III + IV stages (c) and NSCLC tissues with or without lymphoid node metastasis (d). e Survival curve of patients was generated through a Kaplan–Meier plot and analyzed by the log-rank test. f The relative level of circ_0000284 in MRC-5, A549 and H82 cells was assayed through qRT-PCR. All experiments were independently performed three times with N value = 3. *P < 0.05