Fig. 5

Circ_0000284 negatively regulated the expression of miR-377-3p. a Circular RNA Interactome was applied for the bioinformatics analysis of circ_0000284 and miR-377-3p. b, c The binding between circ_0000284 and miR-377-3p was testified by dual-luciferase reporter assay (b) and RIP assay (c). d The overexpression efficiency of circ_0000284 in A549 and H82 cells was assessed via qRT-PCR. e The qRT-PCR was administrated to estimate the effects of circ_0000284 up-regulation or down-regulation on the expression of miR-377-3p. All experiments were independently performed three times with N value = 3. *P < 0.05