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Fig. 1 | Cancer Cell International

Fig. 1

From: miR-363 suppresses the proliferation, migration and invasion of clear cell renal cell carcinoma by downregulating S1PR1

Fig. 1

Expression and prognostic significance of miR-363 in ccRCC and its relationship with S1PR1 expression. a miR-363 expression levels were significantly downregulated in ccRCC tissues compared to adjacent normal tissues. b–d Comparison of miR-363 expression levels between subgroups of patients by clinical stage, T stage and Fuhrman grade. e miR-363 expression in normal renal cell lines and various RCC cell lines. f Kaplan–Meier analysis of ccRCC patients in the low miR-363 group (n = 39) and the high miR-363 group (n = 38) with regard to disease-free survival. g S1PR1 expression levels were markedly upregulated in ccRCC tissues compared to adjacent normal tissues. h and i S1PR1 protein expression in normal renal cell lines and various RCC cell lines. j Negative correlation between S1PR1 mRNA levels and miR-363 levels in ccRCC tissues (n = 77, r = −0.509, P < 0.0001). k Quantitative analysis of S1PR1 relative protein expression in ccRCC tissues and adjacent normal tissues by western blot. l Histoscores of S1PR1 in ccRCC tissues and adjacent normal tissues based on IHC. m Western blot images showed that S1PR1 is upregulated at the protein level in ccRCC tissues, consistent with alterations in mRNA levels in clinical samples. n Representative IHC staining images of S1PR1 in ccRCC tissues and their paired normal tissues. Data are presented as the mean ± SD. (*P < 0.05, **P < 0.01, ***P < 0.001)

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