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Fig. 2 | Cancer Cell International

Fig. 2

From: miR-363 suppresses the proliferation, migration and invasion of clear cell renal cell carcinoma by downregulating S1PR1

Fig. 2

miR-363 inhibits the proliferation, migration and invasion of ccRCC cells in vitro. a Folds change of the miR-363 expression levels in 786O cells transfected with miR-363 mimics or NC mimics. b Folds change of the miR-363 expression levels in 769P cells with the transfection of the miR-363 inhibitor or NC inhibitor. c MTS assay suggested that transfection of the miR-363 mimic inhibited the proliferation of 786O cells and that the miR-363 inhibitor promoted the proliferation of 769P cells. d Colony formation assay suggested that overexpression of miR-363 inhibited the colony number in 786O cells, whereas suppression of miR-363 promoted the colony number in 769P cells. e Transwell assays suggested that overexpression of miR-363 inhibited migration and invasion in 786O cells and that suppression of miR-363 promoted migration and invasion in 769P cells. f Wound healing assay suggested that overexpression of miR-363 inhibited the cell mobility of 786O cells and that suppression of miR-363 promoted the cell mobility of 769P cells. Data are presented as the mean ± SD. (*P < 0.05, **P < 0.01, ***P < 0.001)

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