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Fig. 6 | Cancer Cell International

Fig. 6

From: miR-363 suppresses the proliferation, migration and invasion of clear cell renal cell carcinoma by downregulating S1PR1

Fig. 6

Overexpression of miR-363 suppresses xenograft tumour growth in vivo. a Xenograft tumours were obtained and dissected 8 weeks after subcutaneous injection of 786O cells stably transfected with lentiviral miR-363 particles or empty vector. b Comparison of tumour volume and weight between the miR-363 overexpression group and the EV group (10 mice per group). c, d Alterations in the protein levels of S1PR1, ERK and downstream genes of ERK in xenograft tumours between the miR-363 overexpression group and the EV group. e Histoscores of S1PR1, t-ERK and p-ERK in IHC-stained xenograft tumours between the miR-363 overexpression group and the EV group. f Representative IHC staining images of S1PR1, t-ERK, p-ERK and negative control in xenograft tumours between the miR-363 overexpression group and EV group. Data are presented as the mean ± SD. (*P < 0.05, **P < 0.01, ***P < 0.001)

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