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Table 2 Univariate and multivariate cox regression analysis of clinicopathologic parameters and miR-363 levels with regard to disease-free survival

From: miR-363 suppresses the proliferation, migration and invasion of clear cell renal cell carcinoma by downregulating S1PR1

Variables

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

Age (years)

 < 60

Reference

   

 ≥ 60

0.966 (0.394–2.367)

0.940

  

Gender

 Male

Reference

   

 Female

1.925 (0.699–5.304)

0.205

  

Fuhrman grade

 I–II

Reference

   

 III–IV

1.804 (0.682–4.770)

0.234

  

T staging

 T1–T2

Reference

   

 T3–T4

2.051 (0.777–5.412)

0.147

  

Microvascular invasion

 No

Reference

   

 Yes

1.844 (0.700-4.857)

0.215

  

Tumor necrosis

 No

Reference

   

 Yes

1.237 (0.505–3.033)

0.642

  

Overall TNM staging

 I–II

Reference

 

Reference

 

 III–IV

2.916 (1.190–7.148)

0.019

1.678 (0.616–4.572)

0.311

miR-363 levels

 Low

Reference

 

Reference

 

 High

0.252 (0.092–0.691)

0.007

0.318 (0.103–0.983)

0.047

  1. miR‐363 microRNA‐363, HR hazard ratio, CI confidence interval, TNM tumor node metastasis
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Cancer Cell International

ISSN: 1475-2867

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