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Fig. 3 | Cancer Cell International

Fig. 3

From: CircHIPK3 promotes proliferation and metastasis and inhibits apoptosis of renal cancer cells by inhibiting MiR-485-3p

Fig. 3

CircHIPK3-targeted miR-485-3p could negatively regulate miR-485-3p. a The expressions of circHIPK3 and HIPK3 in the cytoplasm and nucleus were analyzed by qRT-PCR. GAPDH and U6 were used as internal controls. b Circular RNA Interactome predicted that circHIPK3 had a targeting relationship with miR-338-3p, miR-375, miR-485-3p, and miR-495. c QRT-PCR was used to detect the expressions of miR-338-3p, miR-375, miR-485-3p, miR-495. U6 was used as an internal reference. df Dual-luciferase assay was used to verify the targeting relationship between circHIPK3 and miR-485-3p. g The expression of miR-485-3p in RC tissues and adjacent tissues was measured by qRT-PCR (n = 48). h, i Correlation analysis of circHIPK3 and HIPK3 in RC tissues and adjacent tissues (n = 40). ***p < 0.001 vs cytoplasm; ###p < 0.001 vs siNC; &&&p < 0.001 vs MC; ^^p < 0.01 vs IC; +++p < 0.001 vs Adjacent tissues

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