Fig. 7

MiR-485-3p mimic inhibited tumor growth by regulating apoptosis-related genes, while circHIPK3 partially reversed the effect. a Morphology of transplanted tumor. b The weight of the transplanted tumor. c–d Changes of protein expressions of C caspase-3, Bax, and Bcl-2 were detected by Western blot. GAPDH was used as an internal reference. e MRNA expression changes of Bax and Bcl-2 were detected by qRT-PCR. GAPDH was used as an internal reference. ^**p < 0.01, ^***p < 0.001 vs NC + MC; ^{^^}p < 0.01, ^{^^^}p < 0.001 vs NC + M. NC: negative control for circular RNA. MC: mimic control; M: miR-485-3p mimic