Skip to main content
Fig. 5 | Cancer Cell International

Fig. 5

From: LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma cell proliferation and resistance to apoptosis by targeting miR-4656/HDAC11 axis

Fig. 5

ST8SIA6-AS1 upregulated HDAC11 via sponging miR-4656. a Analysis of TCGA data suggested that ST8SIA6-AS1 was positively correlated with HDAC11 expression in HCC. b Knockdown of ST8SIA6-AS1 decreased HDAC11 mRNA level in Huh7 and Hep3B cells. c Knockdown of ST8SIA6-AS1 decreased HDAC11 protein level in Huh7 and Hep3B cells. d miR-4656 mimic decreased HDAC11 mRNA level in Huh7 and Hep3B cells. e miR-4656 mimic decreased HDAC11 protein level in Huh7 and Hep3B cells. f pcDNA3-ST8SIA6-AS1 increased ST8SIA6-AS1 expression in Huh7 and Hep3B cells. g HDAC11 3′UTR-WT (wild type) and HDAC11 3′UTR-Mut (mutant) was inserted into luciferase plasmid. h, i Luciferase reporter assay indicated that miR-4656 mimic repressed luciferase activity of HDAC11 3′UTR-WT which was reversed by transfection of pcDNA3-ST8SIA6-AS1 in Huh7 (h) and Hep3B (i) cells. **p < 0.01; ***p < 0.001

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us