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Fig. 10 | Cancer Cell International

Fig. 10

From: LncRNA LINC00261 overexpression suppresses the growth and metastasis of lung cancer via regulating miR-1269a/FOXO1 axis

Fig. 10

MiR-1269a inhibited the metastasis of LC cells through targeting FOXO1. ac The migration of A549 and SPC-A1 cells was determined by wound-healing assay (magnification: 100x). The migration of A549 and SPC-A1 cells was calculated (b and c). (df) The invasion of A549 and SPC-A1 cells was calculated (d and e). The invaded cells (f) were subjected to transwell assay and shown under a microscope (magnification: 200x). *P < 0.05, **P < 0.001, vs Vector. #P < 0.05, ##P < 0.05 vs. FOXO1. ^P < 0.05, ^^P < 0.05 vs. mimic. Vector: pCDH-CMV empty plasmid. FOXO1: pCDH-CMV-FOXO1 overexpression plasmid. Mimic: miR-1269a mimic. FOXO1 + mimic: pCDH-CMV-FOXO1 and miR-1269a mimic. All experiments repeated independently in triplicate

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