Fig. 5

LINC00261 overexpression inhibited tumor growth in vivo. a, b The xenograft tumor volume in nude mice from LINC00261 overexpression group (n = 3) and NC group (3 mice in each group). c Photographs of tumors at day 30 after LINC00261 transfected A549 and SPC-A1 cells injected into nude mice (3 mice in each group). d, e The tumor weight g in nude mice from LINC00261 overexpression group (n = 3) and NC group (3 mice in each group). f–i The expression levels of FOXO1 were increased in LINC00261 overexpression group, which was detected by IHC. j–k The expression levels of miR-1269a were significantly decreased in LINC00261 overexpression group, which was detected by RT-qPCR. ^**P < 0.001 vs. NC. NC: pCDH-CMV empty plasmid. LINC00261: pCDH-CMV-LINC00261 overexpression plasmid. All experiments repeated independently in triplicate