Fig. 9

MiR-1269a inhibited the apoptosis and cell cycle arrest of LC cells through targeting FOXO1. a–c The apoptosis of A549 and SPC-A1 cells was determined by flow cytometry. d–f The cell cycle of A549 and SPC-A1 cells was determined by flow cytometry. ^*P < 0.05, ^**P < 0.001, vs Vector. ^#P < 0.05, ^##P < 0.05 vs. FOXO1. ^{^}P < 0.05, ^{^^}P < 0.05 vs. mimic. Vector: pCDH-CMV empty plasmid. FOXO1: pCDH-CMV-FOXO1 overexpression plasmid. Mimic: miR-1269a mimic. FOXO1 + mimic: pCDH-CMV-FOXO1 and miR-1269a mimic. All experiments repeated independently in triplicate