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Fig. 2 | Cancer Cell International

Fig. 2

From: TMPO-AS1 promotes cell proliferation of thyroid cancer via sponging miR-498 to modulate TMPO

Fig. 2

TMPO-AS1 positively regulates TMPO in TC. a The location of TMPO-AS1 in chromatin was displayed. b TMPO was upregulated in TC tissues from TCGA database. c There was a positive correlation between TMPO-AS1 and TMPO from GEPIA database. d The expression of TMPO in TC cell lines and human normal thyroid epithelial cell line was detected by QRT-PCR. e QRT-PCR was performed to examine the mRNA expression of TMPO in transfected cells. f Luciferase reporter assay was used to detect the interaction between TMPO-AS1 and TMPO promoter. g It was tested by FISH and subcellular fractionation assays that TMPO-AS1 mainly located in cytoplasm. h RIP assays demonstrated TMPO-AS1 and TMPO were enriched in Ago2 antibody. *p < 0.05, **p < 0.01

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