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Fig. 3 | Cancer Cell International

Fig. 3

From: TMPO-AS1 promotes cell proliferation of thyroid cancer via sponging miR-498 to modulate TMPO

Fig. 3

MiR-498 is downregulated and negatively regulated by TMPO-AS1 as well as represses the growth of TC. a Target genes that could bind with TMPO-AS1 were obtained from starBase and DIANA tools database. b RNA pull down assays selected out miRNAs to bind with TMPO-AS1. c MiR-498 had a binding site for TMPO-AS1. d MiR-498 had a binding site for TMPO. e The expression of miR-498 in TC cell lines and human normal thyroid epithelial cell line was detected by QRT-PCR. f QRT-PCR was used to examine the expression of TMPO in TPC-1 and IHH-4 cells transfected with NC mimics or miR-498 mimics. g QRT-PCR assays were applied to measure the mRNA expression of TMPO in transfected cells. hm The effects of miR-498 on TC growth were assessed by functional assays. **p < 0.01

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