Fig. 5
From: A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway
Lj-1-60 decreases the growth of tumor xenografts in nude mice. a Melanoma cells Sk-Mel-5 (1 × 106 cells) were grafted into nude mice. When tumors reached up to approximately 50 mm3, the tumor-bearing mice were randomized for intraperitoneal injection of 20 or 40 mg/kg of Lj-1-60 once a day for 2–3 weeks as described in “Methods”. b The tumor growth and body weight were measured twice per day. The results are shown as the mean tumor volume ± SD, and an asterisk (***) indicates a significant difference (P < 0.001). c Immunohistochemical staining of ki-67 (a marker of cell proliferation) in the tumor tissues of xenograft nude mice. Data are represented as means (n ≥ 3) ± SD. *P < 0.05