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Fig. 6 | Cancer Cell International

Fig. 6

From: A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway

Fig. 6

Analysis of gene expression profiles involved in melanoma cells altered by Lj-1-60. a The mRNA expression of CDKN1A, GADD45A, MCM3 in melanoma cells Sk-Mel-5 and Sk-Mel-28 was measured by RT-PCR. Total RNA was extracted from the cells treated with 2 μM Lj-1-60 for 24, 48 h. Data were expressed as mean (n = 3) ± SD, *P < 0.05, ***P < 0.001, ****P < 0.0001. b The mRNA expression of CDKN1A, GADD45A, MCM3 in melanoma cells Sk-Mel-5 and Sk-Mel-28 was examined by RT-PCR. Total RNA was extracted from cells knocked down of Fyn with two independent shRNA. Data were expressed as mean (n = 3) ± SD, *P < 0.05, ***P < 0.001, ****P < 0.0001. c Structural model. Lj-1-60 inhibits the proliferation of melanoma and induces cell cycle arrested in G2/M phase and apoptosis by targeting Fyn through inhibiting the phosphorylation of Stat3

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