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Fig. 3 | Cancer Cell International

Fig. 3

From: Arsenic trioxide potentiates Gilteritinib-induced apoptosis in FLT3-ITD positive leukemic cells via IRE1a-JNK-mediated endoplasmic reticulum stress

Fig. 3

Synergistic effects of Gilteritinib and ATO in FLT3-ITD cell lines. ad MV4-11 and MOLM13 cells were treated with Gilteritinib (2.5 nM) and/or ATO (0.5 µM) for 48 h and cell apoptosis was determined by flow cytometry. DMSO treated cells served as a control. Data are shown as the mean ± SD. **P < 0.01, ***P < 0.001. e, f Cellular morphology of the MV4-11 and MOLM13 cells treated with Gilteritinib (2.5 nM) and/or ATO (0.5 µM) for 48 h (Wright–Geimsa staining; magnification, ×1000). Typical features of apoptotic cells were marked by arrows. g, h Transwell assay of MV4-11 and MOLM13 cells treated with Gilteritinib (2.5 nM) and/or ATO (0.5 µM) for 48 h was performed. i, j Cell cycle analysis of MV4-11 cells treated with Gilteritinib (2.5 nM) and/or ATO (0.5 µM) for 48 h was determined by flow cytometry. Data are shown as the mean ± SD. *P < 0.05

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