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Fig. 4 | Cancer Cell International

Fig. 4

From: Arsenic trioxide potentiates Gilteritinib-induced apoptosis in FLT3-ITD positive leukemic cells via IRE1a-JNK-mediated endoplasmic reticulum stress

Fig. 4

ATO at concentration of 0.5 µM has little effect on degradation of FLT3 protein. ad MV4-11 and MOLM13 cells were treated with ATO (0.5 µM) for 48 h and protein levels of FLT3 and USP10 were determined by western blot. Data are shown as the mean ± SD. eh MV4-11 and MOLM13 cells were treated with Gilteritinib (2.5 nM) and/or ATO (0.5 µM) for 48 h and protein levels of P-FLT3 and FLT3 were determined by western blot. Data are shown as the mean ± SD, ***P < 0.001. P-FLT3 phosphorylated-FLT3

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