Table 2 The prognostic significance of ITGA and ITGB superfamily members in predicting OS in HGSOC patients in TCGA dataset
Variables | Number of patients | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | ||
Age | 405 | 1.025 (1.013–1.038) | < 0.001 | 1.023 (1.010–1.036) | < 0.001 |
Stage | 0.078 | 0.116 | |||
Early | 23 | 1 | 1 | ||
Late | 382 | 2.079 (0.922–4.685) | 1.934 (0.850–4.403) | ||
Debulking | 0.017 | 0.230 | |||
Optimal | 302 | 1 | 1 | ||
Suboptimal | 103 | 1.430 (1.065–1.920) | 1.209 (0.887–1.649) | ||
ITGA1 | 405 | 0.745 (0.474–1.170) | 0.202 | / | / |
ITGA2 | 405 | 1.037 (0.713–1.508) | 0.851 | / | / |
ITGA4 | 405 | 1.174 (0.777–1.774) | 0.446 | / | / |
ITGA5 | 405 | 0.922 (0.759–1.120) | 0.416 | / | / |
ITGA6 | 405 | 0.976 (0.819–1.163) | 0.782 | / | / |
ITGA7 | 405 | 0.867 (0.729–1.033) | 0.110 | 0.849 (0.712–1.013) | 0.069 |
ITGA8 | 405 | 0.987 (0.682–1.429) | 0.947 | / | / |
ITGA9 | 405 | 0.944 (0.660–1.348) | 0.750 | / | / |
ITGA10 | 405 | 1.107 (0.756–1.622) | 0.601 | / | / |
ITGB1 | 405 | 1.054 (0.832–1.336) | 0.662 | / | / |
ITGB2 | 405 | 1.004 (0.901–1.118) | 0.945 | / | / |
ITGB3 | 405 | 0.850 (0.501–1.441) | 0.546 | / | / |
ITGB4 | 405 | 0.992 (0.881–1.117) | 0.889 | / | / |
ITGB5 | 405 | 1.087 (0.916–1.290) | 0.341 | / | / |
ITGB6 | 405 | 0.975 (0.759–1.253) | 0.844 | / | / |
ITGB7 | 405 | 0.821 (0.592–1.139) | 0.238 | / | / |
ITGB8 | 405 | 1.207 (1.045–1.394) | 0.011 | 1.175 (1.014–1.362) | 0.032 |