Fig. 2
From: Knockdown of ALPK2 inhibits the development and progression of Ovarian Cancer
Knockdown of ALPK2 inhibits cell proliferation, cell cycle and migration, promotes apoptosis in OC cells. a Cell proliferation of HO-8910 and OVCAR-3 cells with or without knockdown of ALPK2 was evaluated by MTT assay. b The HO-8910 and OVCAR-3 cells in the G1, S and G2 phases of the ALPK2 gene knockdown group and the control group were detected by flow cytometry. c Flow cytometry analysis based on Annexin V-APC staining was utilized to detect the percentage of early apoptotic cell for HO-8910 and OVCAR-3 cells. The X axis indicated the cell apoptosis while the Y axis indicated the green fluorescence detected from the GFP tagged on lentivirus (shALPK2 or shCtrl). d Cell migration of HO-8910 and OVCAR-3 cells with or without knockdown of ALPK2 was evaluated by wound-healing assay. The data were expressed as mean ± SD (n = 3), *P < 0.05, **P < 0.01, ***P < 0.001