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Table 1 The studies supporting the involvement of miR-93 in cancer malignancy

From: Flaming the fight against cancer cells: the role of microRNA-93

In vitro/in vivo Effect on cancer Major results Refs.
Glioblastoma cells Oncogenesis MiR-93 enhances the malignancy and proliferation of glioblastoma cells by inhibition of autophagy via down-regulation of Beclin-1, ATG5, and ATG4B [106]
EC cells Oncogenesis Reducing the capability of radiotherapy by inhibition of BTG3 [125]
HeLa and C‐33A cells cervical cancer tissues Oncogenesis LncRNA ZNF667 suppresses the invasion and malignancy of cancer cells by inhibition of miR-93-3p [311]
Cisplatin-resistant A2780/DDP cell line Oncogenesis Inhibition of miR-93 by l-tetrahydropalmatine is beneficial in sensitizing of cancer cells to cisplatin-mediated apoptosis [312]
Bladder cancer tissues and cells Oncogenesis Upregulation of miR-93 is related to the tumor stage and node stage via stimulation of PEDF [313]
Cervical cancer and matched non-cancerous tissue samples  Oncogenesis Overexpression of miR-93 and inhibition of CDKN1A is associated with poor prognosis of patients [314]
Gastric cancer cells Oncogenesis By inhibition of TIMP2, miR-93 enhances the malignancy of gastric cancer cells [315]
Primary colon cancer cells Oncogenesis By inhibition of miR-93, lncRNA LINC01567 reduces the proliferation an malignancy of cancer cells [316]
Endometrial carcinoma tissues endometrial carcinoma cell lines HEC-1B and Ishikawa Oncogenesis Enhancing the proliferation and malignancy of tumor cells by stimulation of EMT [317]
Ovarian carcinoma cell lines OVCAR3, SKOV3/DDP, and HO8910-PM Oncogenesis MiR-93-5p down-regulates the expression of RhoC to elevate the invasiveness of cancer cells [318]
Human colon cancer tissue and colorectal carcinoma cell lines Oncosuppressor Diminishing the malignancy and migration of cancer cells by inhibition of Wnt signaling pathway [319]
Hep-2 cells cancer tissues Oncogenesis MiR-93 binds to the 3/-UTR of cyclin G2 to inhibit its expression resulting in promoted proliferation of cancer cells [320]
Breast cancer tissues Oncogenesis Overexpression of miR-93 occurs in triple negative breast cancer [321]
Rat model of mammary carcinogenesis Oncogenesis Upregulated miR-93 suppresses the expression of Nrf2 to enhance the tumorigenesis of breast cancer cells [322]
Tumoral and nontumoral colon tissues Oncosuppressor A decrease occurs in the expression of miR-93 in colon cancer cells [323]
Early (recurrence within 12 months after surgery) and non-early relapse CRC patients CRC cells Oncosuppressor Reducing the progression and growth of cancer cells down-regulation of VEGF, p21 and ERBB2 [324]
Cisplatin-resistant ovarian cancer cells Oncosuppressor Upregulation of miR-93 reduces the expression of PTEN to stimulate Akt signaling pathway leading to the sensitization of cancer cells to chemotherapy [325]