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Table 1 The main features of enrolled studies for evaluating DFS

From: Biomarker implication of kallikrein-related peptidases as prognostic tissue substrates of poor survival in colorectal cancer

First author

Year

Ethnicity

KLK type

Sample

Sample size

Detection method

Mean age

TNM stage

Median follow-up time

Hazard ratio

Talieri et al.

2009

Caucasian

KLK7

Tissue

98

qRT-PCR

67.4

I–IV

29

2.05 (1.05–1.00)

Talieri et al.

2009

Caucasian

KLK5

Tissue

127

ELISA

68.7

I–IV

37.2

1.16 (0.99–1.37)

Talieri et al.

2009

Caucasian

KLK6

Tissue

128

ELISA

68.7

I–IV

37.2

1.09 (0.90–1.33)

Talieri et al.

2009

Caucasian

KLK7

Tissue

128

ELISA

68.7

I–IV

37.2

1.28 (0.96–1.72)

Talieri et al.

2009

Caucasian

KLK8

Tissue

128

ELISA

68.7

I–IV

37.2

1.00 (0.80–1.26)

Talieri et al.

2009

Caucasian

KLK10

Tissue

128

ELISA

68.7

I–IV

37.2

1.07 (0.92–1.23)

Talieri et al.

2009

Caucasian

KLK11

Tissue

127

ELISA

68.7

I–IV

37.2

1.12 (0.90–1.39)

Talieri et al.

2009

Caucasian

KLK13

Tissue

128

ELISA

68.7

I–IV

37.2

1.29 (0.98–1.71)

Talieri et al.

2009

Caucasian

KLK14

Tissue

128

ELISA

68.7

I–IV

37.2

1.33 (1.05–1.68)

Talieri et al.

2009

Caucasian

KLK15

Tissue

128

ELISA

68.7

I–IV

37.2

1.12 (0.85–1.46)

Talieri et al.

2011

Caucasian

KLK10

Tissue

119

qRT-PCR

67.45

I–IV

29

2.46 (1.01–6.09)

Kim et al. 

2011

Asian

KLK6

Tissue

143

IHC

NA

I–IV

NA

1.98 (1.18–3.31)

Petraki et al.

2012

Caucasian

KLK6

Tissue

56

IHC

71

I–III

62

1.31 (0.94–1.81)

Petraki et al.

2012

Caucasian

KLK10

Tissue

56

IHC

71

I–III

62

2.54 (0.97–6.64)

Alexopoulou et al.

2013

Caucasian

KLK10

Tissue

121

qRT-PCR

66.5

NA

48.8

2.36 (1.09–5.08)

Kontos et al.

2013

Caucasian

KLK4

Tissue

62

qRT-PCR

66.7

I–IV

NA

2.73 (1.04–7.13)

Devetzi et al.

2013

Caucasian

KLK7

Tissue

95

qRT-PCR

68.4

I–IV

NA

1.47 (0.82–2.64)

Devetzi et al.

2013

Caucasian

KLK14

Tissue

95

qRT-PCR

68.4

I–IV

NA

1.80 (1.10–2.93)

Vakrakou et al.

2014

Caucasian

KLK6

Tissue

92

qRT-PCR

68.2

I–IV

NA

2.85 (0.98–8.27)

Christodoulou et al.

2014

Caucasian

KLK6

Tissue

110

qRT-PCR

65.5

I–IV

NA

4.47 (1.58–12.64)

Alexopoulou et al.

2014

Caucasian

KLK11

Tissue

120

qRT-PCR

69

I–IV

NA

2.89 (1.01–8.30)

Liu et al.

2017

Asian

KLK8

Tissue

124

IHC

NA

I–IV

NA

2.96 (1.48–5.94)

  1. DFS disease-free survival, qRT-PCR quantitative real-time polymerase chain reaction, IHC immunohistochemistry, ELISA enzyme-linked immunosorbent assay, NA not available