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Table 1 The main features of enrolled studies for evaluating DFS

From: Biomarker implication of kallikrein-related peptidases as prognostic tissue substrates of poor survival in colorectal cancer

First authorYearEthnicityKLK typeSampleSample sizeDetection methodMean ageTNM stageMedian follow-up timeHazard ratio
Talieri et al.2009CaucasianKLK7Tissue98qRT-PCR67.4I–IV292.05 (1.05–1.00)
Talieri et al.2009CaucasianKLK5Tissue127ELISA68.7I–IV37.21.16 (0.99–1.37)
Talieri et al.2009CaucasianKLK6Tissue128ELISA68.7I–IV37.21.09 (0.90–1.33)
Talieri et al.2009CaucasianKLK7Tissue128ELISA68.7I–IV37.21.28 (0.96–1.72)
Talieri et al.2009CaucasianKLK8Tissue128ELISA68.7I–IV37.21.00 (0.80–1.26)
Talieri et al.2009CaucasianKLK10Tissue128ELISA68.7I–IV37.21.07 (0.92–1.23)
Talieri et al.2009CaucasianKLK11Tissue127ELISA68.7I–IV37.21.12 (0.90–1.39)
Talieri et al.2009CaucasianKLK13Tissue128ELISA68.7I–IV37.21.29 (0.98–1.71)
Talieri et al.2009CaucasianKLK14Tissue128ELISA68.7I–IV37.21.33 (1.05–1.68)
Talieri et al.2009CaucasianKLK15Tissue128ELISA68.7I–IV37.21.12 (0.85–1.46)
Talieri et al.2011CaucasianKLK10Tissue119qRT-PCR67.45I–IV292.46 (1.01–6.09)
Kim et al. 2011AsianKLK6Tissue143IHCNAI–IVNA1.98 (1.18–3.31)
Petraki et al.2012CaucasianKLK6Tissue56IHC71I–III621.31 (0.94–1.81)
Petraki et al.2012CaucasianKLK10Tissue56IHC71I–III622.54 (0.97–6.64)
Alexopoulou et al.2013CaucasianKLK10Tissue121qRT-PCR66.5NA48.82.36 (1.09–5.08)
Kontos et al.2013CaucasianKLK4Tissue62qRT-PCR66.7I–IVNA2.73 (1.04–7.13)
Devetzi et al.2013CaucasianKLK7Tissue95qRT-PCR68.4I–IVNA1.47 (0.82–2.64)
Devetzi et al.2013CaucasianKLK14Tissue95qRT-PCR68.4I–IVNA1.80 (1.10–2.93)
Vakrakou et al.2014CaucasianKLK6Tissue92qRT-PCR68.2I–IVNA2.85 (0.98–8.27)
Christodoulou et al.2014CaucasianKLK6Tissue110qRT-PCR65.5I–IVNA4.47 (1.58–12.64)
Alexopoulou et al.2014CaucasianKLK11Tissue120qRT-PCR69I–IVNA2.89 (1.01–8.30)
Liu et al.2017AsianKLK8Tissue124IHCNAI–IVNA2.96 (1.48–5.94)
  1. DFS disease-free survival, qRT-PCR quantitative real-time polymerase chain reaction, IHC immunohistochemistry, ELISA enzyme-linked immunosorbent assay, NA not available