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Table 2 The main features of enrolled studies for evaluating OS

From: Biomarker implication of kallikrein-related peptidases as prognostic tissue substrates of poor survival in colorectal cancer

First authorYearEthnicityKLK typeSampleSample sizeDetection methodMean ageTNM stageMedian follow-up timeHazard ratio
Ogawa et al.2005AsianKLK6Tissue63qRT-PCRNAI–IV301.35 (1.13–1.61)
Talieri et al.2009CaucasianKLK7Tissue98qRT-PCR67.4I–IV292.87 (1.33–6.19)
Talieri et al.2009CaucasianKLK5Tissue126ELISA68.7I–IV37.21.24 (1.05–1.47)
Talieri et al.2009CaucasianKLK6Tissue127ELISA68.7I–IV37.21.09 (0.85–1.39)
Talieri et al.2009CaucasianKLK7Tissue127ELISA68.7I–IV37.21.57 (1.04–2.37)
Talieri et al.2009CaucasianKLK8Tissue127ELISA68.7I–IV37.21.01 (0.78–1.32)
Talieri et al.2009CaucasianKLK10Tissue127ELISA68.7I–IV37.21.12 (0.94–1.34)
Talieri et al.2009CaucasianKLK11Tissue126ELISA68.7I–IV37.21.16 (0.91–1.49)
Talieri et al.2009CaucasianKLK13Tissue127ELISA68.7I–IV37.21.36 (1.00–1.87)
Talieri et al.2009CaucasianKLK14Tissue127ELISA68.7I–IV37.21.43 (1.05–1.94)
Talieri et al.2009CaucasianKLK15Tissue127ELISA68.7I–IV37.21.02 (0.77–1.36)
Yu et al.2010AsianKLK11Tissue126IHC59.2I–IVNA1.22 (0.71–2.32)
Inoue et al.2010AsianKLK7Tissue136qRT-PCRNAI–IVNA2.97 (1.36–6.30)
Talieri et al.2011CaucasianKLK10Tissue119qRT-PCR67.4I–IV291.78 (0.67–4.74)
Kim et al. 2011AsianKLK6Tissue143IHCNAI–IVNA2.22 (1.24–3.98)
Petraki et al.2012CaucasianKLK6Tissue56IHC71I–III621.42 (1.02–2.01)
Petraki et al.2012CaucasianKLK10Tissue56IHC71I–III623.63 (1.37–9.63)
Alexopoulou et al.2013CaucasianKLK10Tissue121qRT-PCR66.5NA48.82.75 (1.16–6.52)
Kontos et al.2013CaucasianKLK4Tissue62qRT-PCR66.7I–IVNA1.07 (0.44–2.57)
Devetzi et al.2013CaucasianKLK7Tissue95qRT-PCR68.4I–IVNA1.93 (1.06–3.54)
Devetzi et al.2013CaucasianKLK14Tissue95qRT-PCR68.4I–IVNA2.18 (1.32–3.61)
Vakrakou et al.2014CaucasianKLK6Tissue92qRT-PCR68.2I–IVNA2.71 (0.91–8.08)
Christodoulou et al.2014CaucasianKLK6Tissue110qRT-PCR65.5I–IVNA3.65 (1.27–10.46)
Alexopoulou et al.2014CaucasianKLK11Tissue120qRT-PCR69I–IVNA4.06 (1.18–13.94)
Liu et al.2017AsianKLK8Tissue124IHCNAI–IVNA2.07 (1.11–3.87)
  1. OS overall survival, qRT-PCR quantitative real-time polymerase chain reaction, IHC immunohistochemistry, ELISA enzyme-linked immunosorbent assay, NA not available