Table 3 Results of subgroup analysis of studies for evaluating DFS
Subgroup | Number of studies | HR (95% CI) | PHR | Heterogeneity (I2) | Pheterogeneity |
|---|---|---|---|---|---|
Ethnicity | |||||
Caucasian | 20 | 1.28 (1.16–1.43) | < 0.001 | 46.5% | 0.001 |
Asian | 2 | 2.28 (1.51–3.46) | < 0.001 | 0% | 0.012 |
KLK member | |||||
KLK4 | 1 | 2.73 (1.04–7.15) | – | – | – |
KLK5 | 1 | 1.16 (0.99–1.37) | – | – | – |
KLK6 | 5 | 1.63 (1.12–2.39) | 0.012 | 69.4% | 0.011 |
KLK7 | 3 | 1.39 (1.09–1.78) | 0.007 | 0% | 0.441 |
KLK8 | 2 | 1.63 (0.57–4.71) | 0.363 | 88.2% | 0.004 |
KLK10 | 4 | 1.79 (1.00–3.20) | 0.05 | 68.9% | 0.022 |
KLK11 | 2 | 1.55 (0.64–3.76) | 0.328 | 66.5% | 0.084 |
KLK13 | 1 | 1.29 (0.98–1.71) | – | – | – |
KLK14 | 2 | 1.43 (1.11–1.84) | 0.041 | 16.1% | 0.275 |
KLK15 | 1 | 1.12 (0.85–1.46) | – | – | – |
Detection method | |||||
qRT-PCR | 9 | 2.12 (1.66–2.73) | < 0.001 | 0% | 0.725 |
IHC | 4 | 1.89 (1.27–2.81) | 0.002 | 48.9% | 0.118 |
ELISA | 9 | 1.13 (1.06–2.81) | < 0.001 | 0% | 0.725 |