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Table 3 Results of subgroup analysis of studies for evaluating DFS

From: Biomarker implication of kallikrein-related peptidases as prognostic tissue substrates of poor survival in colorectal cancer

SubgroupNumber of studiesHR (95% CI)PHRHeterogeneity (I2)Pheterogeneity
Ethnicity
 Caucasian201.28 (1.16–1.43)< 0.00146.5%0.001
 Asian22.28 (1.51–3.46)< 0.0010%0.012
KLK member
 KLK412.73 (1.04–7.15)
 KLK511.16 (0.99–1.37)
 KLK651.63 (1.12–2.39)0.01269.4%0.011
 KLK731.39 (1.09–1.78)0.0070%0.441
 KLK821.63 (0.57–4.71)0.36388.2%0.004
 KLK1041.79 (1.00–3.20)0.0568.9%0.022
 KLK1121.55 (0.64–3.76)0.32866.5%0.084
 KLK1311.29 (0.98–1.71)
 KLK1421.43 (1.11–1.84)0.04116.1%0.275
 KLK1511.12 (0.85–1.46)
Detection method
 qRT-PCR92.12 (1.66–2.73)< 0.0010%0.725
 IHC41.89 (1.27–2.81)0.00248.9%0.118
 ELISA91.13 (1.06–2.81)< 0.0010%0.725
  1. qRT-PCR quantitative real-time polymerase chain reaction, IHC immunohistochemistry, ELISA enzyme-linked immunosorbent assay