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Table 4 Results of subgroup analysis of studies for evaluating OS

From: Biomarker implication of kallikrein-related peptidases as prognostic tissue substrates of poor survival in colorectal cancer

SubgroupNumber of studiesHR (95% CI)PHRHeterogeneity (I2)Pheterogeneity
Ethnicity
 Caucasian201.38 (1.21–1.56)< 0.00151.5%0.004
 Asian51.69 (1.25–2.30)< 0.00147.2%0.108
KLK member
 KLK411.07 (0.44–2.57)
 KLK511.24 (1.05–1.47)
 KLK661.47 (1.16–1.86)0.00153.6%0.056
 KLK741.98 (1.46–2.68)< 0.0016%0.363
 KLK821.36 (0.68–2.73)0.38076.8%0.038
 KLK1041.90 (1.01–3.58)0.04669%0.022
 KLK1131.36 (0.86–2.14)0.18747.4%0.149
 KLK1311.36 (1.00–1.87)
 KLK1421.68 (1.12–2.51)0.01149.2%0.161
 KLK1511.02 (0.77–1.36)
Detection method
 qRT-PCR112.06 (1.57–2.72)< 0.00144%0.058
 IHC51.74 (1.28–2.35)< 0.00130.6%0.218
 ELISA91.18 (1.09–1.28)< 0.0010%0.476
  1. qRT-PCR quantitative real-time polymerase chain reaction, IHC immunohistochemistry, ELISA enzyme-linked immunosorbent assay