Subgroup | Number of studies | HR (95% CI) | PHR | Heterogeneity (I2) | Pheterogeneity |
---|---|---|---|---|---|
Ethnicity | |||||
Caucasian | 20 | 1.38 (1.21–1.56) | < 0.001 | 51.5% | 0.004 |
Asian | 5 | 1.69 (1.25–2.30) | < 0.001 | 47.2% | 0.108 |
KLK member | |||||
KLK4 | 1 | 1.07 (0.44–2.57) | – | – | – |
KLK5 | 1 | 1.24 (1.05–1.47) | – | – | – |
KLK6 | 6 | 1.47 (1.16–1.86) | 0.001 | 53.6% | 0.056 |
KLK7 | 4 | 1.98 (1.46–2.68) | < 0.001 | 6% | 0.363 |
KLK8 | 2 | 1.36 (0.68–2.73) | 0.380 | 76.8% | 0.038 |
KLK10 | 4 | 1.90 (1.01–3.58) | 0.046 | 69% | 0.022 |
KLK11 | 3 | 1.36 (0.86–2.14) | 0.187 | 47.4% | 0.149 |
KLK13 | 1 | 1.36 (1.00–1.87) | – | – | – |
KLK14 | 2 | 1.68 (1.12–2.51) | 0.011 | 49.2% | 0.161 |
KLK15 | 1 | 1.02 (0.77–1.36) | – | – | – |
Detection method | |||||
qRT-PCR | 11 | 2.06 (1.57–2.72) | < 0.001 | 44% | 0.058 |
IHC | 5 | 1.74 (1.28–2.35) | < 0.001 | 30.6% | 0.218 |
ELISA | 9 | 1.18 (1.09–1.28) | < 0.001 | 0% | 0.476 |