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Table 3 Univariate and multivariate Cox regression analyses, prognosis-related clinical factors, and clinical independence

From: Co-expression network analysis identifies a gene signature as a predictive biomarker for energy metabolism in osteosarcoma

VariablesUnivariate analysisMultivariable analysis
HR95% CI of HRP valueHR95% CI of HRP value
TARGET training datasets
 7-gene risk score
  Risk score (high/low)19.874.67–84.423.11E−0428.896.25–133.41.63E−05
  Age0.990.90–1.090.831.121.00–1.240.048
  Gender (male/female)0.570.25–1.270.170.570.24–1.330.19
  Metastatic vs non-metastatic4.181.92–9.100.00035.342.21–12.950.0002
TARGET datasets
 7-gene risk score
  Risk score (high/low)17.294.10–72.961.04E−0421.074.87–91.214.54E−05
  Age0.990.91–1.070.811.080.98––1.190.098
  Gender (male/female)0.760.36–1.600.470.760.35–1.640.48
  Metastatic vs Non-metastatic4.742.27–9.893.42E−055.692.54–12.762.36E−05
GSE21257 validation datasets
 7-gene risk score
  Risk score (high/low)2.841.23–6.550.0142.761.18–6.460.0186
  Age1.00070.99–1.0030.60210.99–1.0030.787
  Gender (male/female)1.40.58–3.340.441.390.56–3.410.468