Table 3 Univariate and multivariate Cox regression analyses, prognosis-related clinical factors, and clinical independence
Variables | Univariate analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI of HR | P value | HR | 95% CI of HR | P value | |
TARGET training datasets | ||||||
7-gene risk score | ||||||
Risk score (high/low) | 19.87 | 4.67–84.42 | 3.11E−04 | 28.89 | 6.25–133.4 | 1.63E−05 |
Age | 0.99 | 0.90–1.09 | 0.83 | 1.12 | 1.00–1.24 | 0.048 |
Gender (male/female) | 0.57 | 0.25–1.27 | 0.17 | 0.57 | 0.24–1.33 | 0.19 |
Metastatic vs non-metastatic | 4.18 | 1.92–9.10 | 0.0003 | 5.34 | 2.21–12.95 | 0.0002 |
TARGET datasets | ||||||
7-gene risk score | ||||||
Risk score (high/low) | 17.29 | 4.10–72.96 | 1.04E−04 | 21.07 | 4.87–91.21 | 4.54E−05 |
Age | 0.99 | 0.91–1.07 | 0.81 | 1.08 | 0.98––1.19 | 0.098 |
Gender (male/female) | 0.76 | 0.36–1.60 | 0.47 | 0.76 | 0.35–1.64 | 0.48 |
Metastatic vs Non-metastatic | 4.74 | 2.27–9.89 | 3.42E−05 | 5.69 | 2.54–12.76 | 2.36E−05 |
GSE21257 validation datasets | ||||||
7-gene risk score | ||||||
Risk score (high/low) | 2.84 | 1.23–6.55 | 0.014 | 2.76 | 1.18–6.46 | 0.0186 |
Age | 1.0007 | 0.99–1.003 | 0.602 | 1 | 0.99–1.003 | 0.787 |
Gender (male/female) | 1.4 | 0.58–3.34 | 0.44 | 1.39 | 0.56–3.41 | 0.468 |