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Table 3 Summary of differential metabolites between OS and OSC

From: Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

 Metabolite143BMG63
VIPP valueFCVIPP valueFC
Amino acidProlyl-Threonine2.596.43 × 10−150.041.761.72 × 10−120.13
S-Methyl-5′-thioadenosine2.233.60 × 10−051.213.385.45 × 10−122.44
S-Adenosyl-L-homocysteine3.541.03 × 10−0835.321.001.95 × 10−0511.05
NAAG1.065.40 × 10−071.611.421.92 × 10−087.63
Glutathione12.131.11 × 10−1416.905.252.69 × 10−0810.60
Glutathione disulfide1.041.21 × 10−41.131.701.07 × 10−051.80
L-Malic acid2.717.98 × 10−108.121.733.57 × 10−091.53
N-Acetyl-l-aspartic acid3.867.27 × 10−113.104.393.57 × 10−081.53
Harman7.247.07 × 10−090.667.571.08 × 10−110.39
Indole-3-carboxylic acid1.567.89 × 10−0929.181.082.07 × 10−1015.99
Fatty acidsErucic acid1.254.48 × 10−050.762.025.28 × 10−110.18
Erucamide11.381.41 × 10−050.7116.666.28 × 10−100.14
Linoleic acid3.902.82 × 10−107.632.534.03 × 10−44.64
Stearic acid3.781.54 × 10−070.633.892.15 × 10−100.48
Capric acid2.574.40 × 10−090.621.772.32 × 10−080.66
Desmosterol3.125.16 × 10−090.233.688.14 × 10−110.25
Undecanoic Acid1.962.63 × 10−100.411.175.61 × 10−100.49
Stearoylcarnitine6.892.06 × 10−120.199.862.68 × 10−110.33
LysoPE(16:0/0:0)3.563.47 × 10−102.294.653.28 × 10−124.89
25-Hydroxycholesterol3.231.12 × 10−080.212.241.51 × 10−090.15
LysoPE(18:0/0:0)1.736.86 × 10−112.911.445.23 × 10−112.48
LysoPC(16:0)13.452.66 × 10−101.8014.171.02 × 10−123.12
LysoPC(O-18:0)5.873.91 × 10−123.212.071.50 × 10−071.23
SOPC3.606.80 × 10−30.634.522.21 × 10−130.28
Phosphorylcholine1.581.63 × 10−090.252.972.93 × 10−130.07
16-Hydroxypalmitic acid1.235.22 × 10−093.132.602.63 × 10−144.86
Oleic acid1.534.42 × 10−051.722.494.40 × 10−072.26
LysoPE(16:0/0:0)4.261.74 × 10−102.338.061.48 × 10−123.97
Retinol2.721.05 × 10−1410.701.831.85 × 10−128.09
Geranyl diphosphate3.516.76 × 10−130.034.063.83 × 10−160.02
CarbohydratesUDP-d-Glucose3.237.36 × 10−094.242.327.16 × 10−052.24
d-Fructose 1,6-bisphosphate3.381.98 × 10−060.131.351.08 × 10−070.49
Nucleic acid2′-O-methylcytidine3.921.37 × 10−110.264.054.73 × 10−140.11
Adenosine 3′-monophosphate4.679.90 × 10−1613.532.048.97 × 10−107.84
UDP3.869.19 × 10−106.383.111.14 × 10−092.26
UTP2.337.48 × 10−055.582.101.42 × 10−33.84
dGTP9.721.21 × 10−052.475.471.90 × 10−21.32
  1. VIP Variable Importance for the Project, FC fold change, NAAG N-Acetylaspartylglutamate, SOPC 1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine, UDP-d-Glucose Uridine diphosphate glucose, UDP Uridine 5′-diphosphate, UTP Uridine 5′-triphosphate, dGTP deoxyguanosine triphosphate