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Table 4 Summary of differential metabolites between OS and OS-IC50

From: Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

 Metabolite143BMG63
VIPP valueFCVIPP valueFC
Amino acidsLysyl-Glycine1.831.56 × 10−040.142.374.07 × 10−040.67
Prolyl-Valine1.721.35 × 10−070.131.881.85 × 10−050.67
Alanyl-Isoleucine1.481.03 × 10−090.051.251.42 × 10−050.83
l-Proline1.113.07 × 10−040.092.175.75 × 10−040.36
L-prolyl-l-phenylalanine1.581.73 × 10−040.251.851.52 × 10−030.82
Histidinyl-Methionine1.531.37 × 10−070.164.036.46 × 10−070.17
Phenylalanyl-Alanine5.825.70 × 10−090.048.222.12 × 10−080.68
Isoleucyl-Tyrosine2.461.04 × 10−050.123.293.24 × 10−060.59
Phenylalanyl-Glutamate1.688.19 × 10−070.142.076.45 × 10−060.59
Ornithine1.108.96 × 10−060.051.511.09 × 10−090.48
Valyl-Tryptophan1.777.45 × 10−100.093.472.38 × 10−090.37
NAAG1.272.53 × 10−106.581.371.11 × 10−042.12
Alpha-N-Phenylacetyl-l-glutamine1.597.87 × 10−080.032.015.01 × 10−060.43
N-(omega)-Hydroxyarginine1.034.98 × 10−040.211.152.16 × 10−030.44
gamma-L-Glutamyl-l-phenylalanine1.221.12 × 10−080.181.133.80 × 10−070.62
S-Adenosyl-L-homocysteine2.331.61 × 10−063.201.224.99 × 10−056.00
Phenylalanyl-Tryptophan1.355.22 × 10−080.141.511.87 × 10−060.67
Valyl-Methionine1.334.65 × 10−080.101.372.91 × 10−030.61
Leucyl-Glutamine1.568.20 × 10−080.052.153.86 × 10−080.24
L-Malic acid2.491.79 × 10−083.361.563.83 × 10−081.38
Citrate4.621.53 × 10−103.112.121.07 × 10−061.37
Glutathione5.652.45 × 10−061.515.551.29 × 10−062.62
Tyrosyl-Serine1.267.82 × 10−060.101.726.27 × 10−080.53
Methionyl-Tyrosine1.222.91 × 10−070.101.332.37 × 10−060.60
Phenylalanylphenylalanine2.847.23 × 10−090.093.663.80 × 10−080.64
Isoleucyl-Tryptophan1.857.53 × 10−060.143.561.89 × 10−050.42
Phenylalanyl-Tyrosine1.947.19 × 10−060.211.962.50 × 10−020.65
7,8-Dihydrobiopterin1.412.99 × 10−060.052.741.58 × 10−080.41
Fatty acidsDesmosterol2.621.23 × 10−060.211.251.99 × 10−030.79
7-Ketocholesterol1.181.61 × 10−031.721.331.87 × 10−052.53
Undecanedioic acid1.064.26 × 10−050.271.185.06 × 10−050.69
Erucamide11.911.43 × 10−062.934.201.68 × 10−061.31
Linoleic acid1.472.22 × 10−021.353.373.04 × 10−045.31
LysoPC(O-18:0)3.375.08 × 10−041.664.575.32 × 10−112.21
Oleic acid1.414.01 × 10−040.741.863.45 × 10−040.75
Arachidonic Acid (peroxide free)1.254.31 × 10−040.783.661.96 × 10−080.41
LysoPC(18:1(9Z))2.908.94 × 10−060.481.921.24 × 10−040.63
LysoPE(16:0/0:0)3.531.59 × 10−081.596.351.11 × 10−042.00
PE(16:0/18:1(9Z))1.222.94 × 10−072.672.341.11 × 10−093.97
PC(16:0/16:0)4.221.30 × 10−104.994.182.97 × 10−103.98
PS(18:0/18:1(9Z))1.022.56 × 10−072.432.142.18 × 10−083.83
PC(18:1(9Z)/18:1(9Z))11.582.25 × 10−084.086.545.93 × 10−076.44
SOPC3.694.05 × 10−093.373.014.32 × 10−093.45
EnergyADP4.794.17 × 10−061.943.106.91 × 10−071.63
GDP1.411.24 × 10−050.721.411.24 × 10−050.72
GTP2.214.37 × 10−032.032.045.37 × 10−043.14
Nucleic acid2′-O-methylcytidine2.702.18 × 10−100.321.752.30 × 10−070.51
CTP1.508.34 × 10−051.562.083.40 × 10−061.65
UTP2.086.54 × 10−042.862.305.85 × 10−045.88
dGTP10.361.05 × 10−052.5712.586.78 × 10−086.97
Uridine1.116.61 × 10−070.232.194.02 × 10−090.18
Inosine1.723.86 × 10−090.245.841.41 × 10−070.27
Thymidine2.052.01 × 10−120.124.593.33 × 10−120.13
Adenosine 3′-monophosphate2.503.86 × 10−081.792.332.24 × 10−073.34
UDP1.498.75 × 10−040.441.287.28 × 10−050.63
UDP-D-Galactose4.912.72 × 10−060.331.622.33 × 10−060.62
  1. VIP Variable Importance for the Project, FC fold change, NAAG N-Acetylaspartylglutamate, SOPC 1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine, ADP adenosine 5′-diphosphate, GDP Guanosine 5′-diphosphate, GTP Guanosine 5′-triphosphate, CTP Cytidine triphosphate, UTP Uridine 5′-triphosphate, dGTP Deoxyguanosine triphosphate, UDP Uridine 5′-diphosphate