Table 4 Summary of differential metabolites between OS and OS-IC50
Metabolite | 143B | MG63 | |||||
|---|---|---|---|---|---|---|---|
VIP | P value | FC | VIP | P value | FC | ||
Amino acids | Lysyl-Glycine | 1.83 | 1.56 × 10−04 | 0.14 | 2.37 | 4.07 × 10−04 | 0.67 |
Prolyl-Valine | 1.72 | 1.35 × 10−07 | 0.13 | 1.88 | 1.85 × 10−05 | 0.67 | |
Alanyl-Isoleucine | 1.48 | 1.03 × 10−09 | 0.05 | 1.25 | 1.42 × 10−05 | 0.83 | |
l-Proline | 1.11 | 3.07 × 10−04 | 0.09 | 2.17 | 5.75 × 10−04 | 0.36 | |
L-prolyl-l-phenylalanine | 1.58 | 1.73 × 10−04 | 0.25 | 1.85 | 1.52 × 10−03 | 0.82 | |
Histidinyl-Methionine | 1.53 | 1.37 × 10−07 | 0.16 | 4.03 | 6.46 × 10−07 | 0.17 | |
Phenylalanyl-Alanine | 5.82 | 5.70 × 10−09 | 0.04 | 8.22 | 2.12 × 10−08 | 0.68 | |
Isoleucyl-Tyrosine | 2.46 | 1.04 × 10−05 | 0.12 | 3.29 | 3.24 × 10−06 | 0.59 | |
Phenylalanyl-Glutamate | 1.68 | 8.19 × 10−07 | 0.14 | 2.07 | 6.45 × 10−06 | 0.59 | |
Ornithine | 1.10 | 8.96 × 10−06 | 0.05 | 1.51 | 1.09 × 10−09 | 0.48 | |
Valyl-Tryptophan | 1.77 | 7.45 × 10−10 | 0.09 | 3.47 | 2.38 × 10−09 | 0.37 | |
NAAG | 1.27 | 2.53 × 10−10 | 6.58 | 1.37 | 1.11 × 10−04 | 2.12 | |
Alpha-N-Phenylacetyl-l-glutamine | 1.59 | 7.87 × 10−08 | 0.03 | 2.01 | 5.01 × 10−06 | 0.43 | |
N-(omega)-Hydroxyarginine | 1.03 | 4.98 × 10−04 | 0.21 | 1.15 | 2.16 × 10−03 | 0.44 | |
gamma-L-Glutamyl-l-phenylalanine | 1.22 | 1.12 × 10−08 | 0.18 | 1.13 | 3.80 × 10−07 | 0.62 | |
S-Adenosyl-L-homocysteine | 2.33 | 1.61 × 10−06 | 3.20 | 1.22 | 4.99 × 10−05 | 6.00 | |
Phenylalanyl-Tryptophan | 1.35 | 5.22 × 10−08 | 0.14 | 1.51 | 1.87 × 10−06 | 0.67 | |
Valyl-Methionine | 1.33 | 4.65 × 10−08 | 0.10 | 1.37 | 2.91 × 10−03 | 0.61 | |
Leucyl-Glutamine | 1.56 | 8.20 × 10−08 | 0.05 | 2.15 | 3.86 × 10−08 | 0.24 | |
L-Malic acid | 2.49 | 1.79 × 10−08 | 3.36 | 1.56 | 3.83 × 10−08 | 1.38 | |
Citrate | 4.62 | 1.53 × 10−10 | 3.11 | 2.12 | 1.07 × 10−06 | 1.37 | |
Glutathione | 5.65 | 2.45 × 10−06 | 1.51 | 5.55 | 1.29 × 10−06 | 2.62 | |
Tyrosyl-Serine | 1.26 | 7.82 × 10−06 | 0.10 | 1.72 | 6.27 × 10−08 | 0.53 | |
Methionyl-Tyrosine | 1.22 | 2.91 × 10−07 | 0.10 | 1.33 | 2.37 × 10−06 | 0.60 | |
Phenylalanylphenylalanine | 2.84 | 7.23 × 10−09 | 0.09 | 3.66 | 3.80 × 10−08 | 0.64 | |
Isoleucyl-Tryptophan | 1.85 | 7.53 × 10−06 | 0.14 | 3.56 | 1.89 × 10−05 | 0.42 | |
Phenylalanyl-Tyrosine | 1.94 | 7.19 × 10−06 | 0.21 | 1.96 | 2.50 × 10−02 | 0.65 | |
7,8-Dihydrobiopterin | 1.41 | 2.99 × 10−06 | 0.05 | 2.74 | 1.58 × 10−08 | 0.41 | |
Fatty acids | Desmosterol | 2.62 | 1.23 × 10−06 | 0.21 | 1.25 | 1.99 × 10−03 | 0.79 |
7-Ketocholesterol | 1.18 | 1.61 × 10−03 | 1.72 | 1.33 | 1.87 × 10−05 | 2.53 | |
Undecanedioic acid | 1.06 | 4.26 × 10−05 | 0.27 | 1.18 | 5.06 × 10−05 | 0.69 | |
Erucamide | 11.91 | 1.43 × 10−06 | 2.93 | 4.20 | 1.68 × 10−06 | 1.31 | |
Linoleic acid | 1.47 | 2.22 × 10−02 | 1.35 | 3.37 | 3.04 × 10−04 | 5.31 | |
LysoPC(O-18:0) | 3.37 | 5.08 × 10−04 | 1.66 | 4.57 | 5.32 × 10−11 | 2.21 | |
Oleic acid | 1.41 | 4.01 × 10−04 | 0.74 | 1.86 | 3.45 × 10−04 | 0.75 | |
Arachidonic Acid (peroxide free) | 1.25 | 4.31 × 10−04 | 0.78 | 3.66 | 1.96 × 10−08 | 0.41 | |
LysoPC(18:1(9Z)) | 2.90 | 8.94 × 10−06 | 0.48 | 1.92 | 1.24 × 10−04 | 0.63 | |
LysoPE(16:0/0:0) | 3.53 | 1.59 × 10−08 | 1.59 | 6.35 | 1.11 × 10−04 | 2.00 | |
PE(16:0/18:1(9Z)) | 1.22 | 2.94 × 10−07 | 2.67 | 2.34 | 1.11 × 10−09 | 3.97 | |
PC(16:0/16:0) | 4.22 | 1.30 × 10−10 | 4.99 | 4.18 | 2.97 × 10−10 | 3.98 | |
PS(18:0/18:1(9Z)) | 1.02 | 2.56 × 10−07 | 2.43 | 2.14 | 2.18 × 10−08 | 3.83 | |
PC(18:1(9Z)/18:1(9Z)) | 11.58 | 2.25 × 10−08 | 4.08 | 6.54 | 5.93 × 10−07 | 6.44 | |
SOPC | 3.69 | 4.05 × 10−09 | 3.37 | 3.01 | 4.32 × 10−09 | 3.45 | |
Energy | ADP | 4.79 | 4.17 × 10−06 | 1.94 | 3.10 | 6.91 × 10−07 | 1.63 |
GDP | 1.41 | 1.24 × 10−05 | 0.72 | 1.41 | 1.24 × 10−05 | 0.72 | |
GTP | 2.21 | 4.37 × 10−03 | 2.03 | 2.04 | 5.37 × 10−04 | 3.14 | |
Nucleic acid | 2′-O-methylcytidine | 2.70 | 2.18 × 10−10 | 0.32 | 1.75 | 2.30 × 10−07 | 0.51 |
CTP | 1.50 | 8.34 × 10−05 | 1.56 | 2.08 | 3.40 × 10−06 | 1.65 | |
UTP | 2.08 | 6.54 × 10−04 | 2.86 | 2.30 | 5.85 × 10−04 | 5.88 | |
dGTP | 10.36 | 1.05 × 10−05 | 2.57 | 12.58 | 6.78 × 10−08 | 6.97 | |
Uridine | 1.11 | 6.61 × 10−07 | 0.23 | 2.19 | 4.02 × 10−09 | 0.18 | |
Inosine | 1.72 | 3.86 × 10−09 | 0.24 | 5.84 | 1.41 × 10−07 | 0.27 | |
Thymidine | 2.05 | 2.01 × 10−12 | 0.12 | 4.59 | 3.33 × 10−12 | 0.13 | |
Adenosine 3′-monophosphate | 2.50 | 3.86 × 10−08 | 1.79 | 2.33 | 2.24 × 10−07 | 3.34 | |
UDP | 1.49 | 8.75 × 10−04 | 0.44 | 1.28 | 7.28 × 10−05 | 0.63 | |
UDP-D-Galactose | 4.91 | 2.72 × 10−06 | 0.33 | 1.62 | 2.33 × 10−06 | 0.62 | |