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Table 6 Summary of differential metabolites between OS-IC50 and OSC-IC50

From: Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

 Metabolite143BMG63
VIPP valueFCVIPP valueFC
Amino acidsProlyl-Threonine2.239.27 × 10−130.071.561.07 × 10−090.33
Histidinyl-Methionine1.549.25 × 10−073.234.102.82 × 10−088.27
S-Methyl-5′-thioadenosine2.313.54 × 10−021.602.076.89 × 10−081.47
Isoleucyl-Valine1.772.33 × 10−041.313.423.10 × 10−1013.49
Glutathione disulfide1.982.59 × 10−041.603.061.58 × 10−0911.05
l-Phenylalanine3.808.28 × 10−053.541.547.72 × 10−051.44
l-Tryptophan4.171.10 × 10−123.701.611.67 × 10−061.43
Fatty acidsPG(16:0/18:1(9Z))2.141.32 × 10−030.321.591.70 × 10−070.36
N-Oleoylethanolamine2.363.55 × 10−062.011.708.55 × 10−061.66
Stearoylcarnitine7.762.80 × 10−130.115.181.67 × 10−040.81
LysoPE(16:0/0:0)2.271.40 × 10−040.764.661.03 × 10−090.55
LysoPE(20:3(8Z,11Z,14Z)/0:0)1.492.08 × 10−040.521.588.2 × 10−080.61
LysoPC(18:1(9Z))4.112.08 × 10−076.032.052.01 × 10−041.78
Phosphorylcholine1.176.13 × 10−050.591.225.24 × 10−060.41
Arachidonic Acid (peroxide free)1.251.16 × 10−031.232.382.08 × 10−061.61
LysoPE(16:0/0:0)4.171.33 × 10−080.602.643.96 × 10−020.73
Cholesterol sulfate1.924.56 × 10−054.871.323.81 × 10−068.33
Geranyl diphosphate3.511.67 × 10−130.031.951.72 × 10−090.08
Nucleic acidInosine1.862.57 × 10−093.445.391.50 × 10−0812.82
Uridine1.142.49 × 10−062.911.833.42 × 10−096.46
Thymidine2.052.68 × 10−113.363.754.10 × 10−126.95
2′-O-methylcytidine2.518.08 × 10−070.684.331.19 × 10−090.25
 dGTP4.712.72 × 10−020.724.001.28 × 10−040.50
  1. VIP Variable Importance for the Project, FC fold change, dGTP Deoxyguanosine triphosphate