Table 6 Summary of differential metabolites between OS-IC50 and OSC-IC50
Metabolite | 143B | MG63 | |||||
|---|---|---|---|---|---|---|---|
VIP | P value | FC | VIP | P value | FC | ||
Amino acids | Prolyl-Threonine | 2.23 | 9.27 × 10−13 | 0.07 | 1.56 | 1.07 × 10−09 | 0.33 |
Histidinyl-Methionine | 1.54 | 9.25 × 10−07 | 3.23 | 4.10 | 2.82 × 10−08 | 8.27 | |
S-Methyl-5′-thioadenosine | 2.31 | 3.54 × 10−02 | 1.60 | 2.07 | 6.89 × 10−08 | 1.47 | |
Isoleucyl-Valine | 1.77 | 2.33 × 10−04 | 1.31 | 3.42 | 3.10 × 10−10 | 13.49 | |
Glutathione disulfide | 1.98 | 2.59 × 10−04 | 1.60 | 3.06 | 1.58 × 10−09 | 11.05 | |
l-Phenylalanine | 3.80 | 8.28 × 10−05 | 3.54 | 1.54 | 7.72 × 10−05 | 1.44 | |
l-Tryptophan | 4.17 | 1.10 × 10−12 | 3.70 | 1.61 | 1.67 × 10−06 | 1.43 | |
Fatty acids | PG(16:0/18:1(9Z)) | 2.14 | 1.32 × 10−03 | 0.32 | 1.59 | 1.70 × 10−07 | 0.36 |
N-Oleoylethanolamine | 2.36 | 3.55 × 10−06 | 2.01 | 1.70 | 8.55 × 10−06 | 1.66 | |
Stearoylcarnitine | 7.76 | 2.80 × 10−13 | 0.11 | 5.18 | 1.67 × 10−04 | 0.81 | |
LysoPE(16:0/0:0) | 2.27 | 1.40 × 10−04 | 0.76 | 4.66 | 1.03 × 10−09 | 0.55 | |
LysoPE(20:3(8Z,11Z,14Z)/0:0) | 1.49 | 2.08 × 10−04 | 0.52 | 1.58 | 8.2 × 10−08 | 0.61 | |
LysoPC(18:1(9Z)) | 4.11 | 2.08 × 10−07 | 6.03 | 2.05 | 2.01 × 10−04 | 1.78 | |
Phosphorylcholine | 1.17 | 6.13 × 10−05 | 0.59 | 1.22 | 5.24 × 10−06 | 0.41 | |
Arachidonic Acid (peroxide free) | 1.25 | 1.16 × 10−03 | 1.23 | 2.38 | 2.08 × 10−06 | 1.61 | |
LysoPE(16:0/0:0) | 4.17 | 1.33 × 10−08 | 0.60 | 2.64 | 3.96 × 10−02 | 0.73 | |
Cholesterol sulfate | 1.92 | 4.56 × 10−05 | 4.87 | 1.32 | 3.81 × 10−06 | 8.33 | |
Geranyl diphosphate | 3.51 | 1.67 × 10−13 | 0.03 | 1.95 | 1.72 × 10−09 | 0.08 | |
Nucleic acid | Inosine | 1.86 | 2.57 × 10−09 | 3.44 | 5.39 | 1.50 × 10−08 | 12.82 |
Uridine | 1.14 | 2.49 × 10−06 | 2.91 | 1.83 | 3.42 × 10−09 | 6.46 | |
Thymidine | 2.05 | 2.68 × 10−11 | 3.36 | 3.75 | 4.10 × 10−12 | 6.95 | |
2′-O-methylcytidine | 2.51 | 8.08 × 10−07 | 0.68 | 4.33 | 1.19 × 10−09 | 0.25 | |
dGTP | 4.71 | 2.72 × 10−02 | 0.72 | 4.00 | 1.28 × 10−04 | 0.50 | |