TY - JOUR AU - Zappa, C. AU - Mousa, S. A. PY - 2016 DA - 2016// TI - Non-small cell lung cancer: current treatment and future advances JO - Transl Lung Cancer Res. VL - 5 UR - https://doi.org/10.21037/tlcr.2016.06.07 DO - 10.21037/tlcr.2016.06.07 ID - Zappa2016 ER - TY - JOUR AU - Gridelli, C. AU - Rossi, A. AU - Carbone, D. P. AU - Guarize, J. AU - Karachaliou, N. AU - Mok, T. PY - 2015 DA - 2015// TI - Non-small-cell lung cancer JO - Nat Rev Dis Primers. VL - 1 UR - https://doi.org/10.1038/nrdp.2015.9 DO - 10.1038/nrdp.2015.9 ID - Gridelli2015 ER - TY - JOUR AU - Torre, L. A. AU - Bray, F. AU - Siegel, R. L. AU - Ferlay, J. AU - Lortet-Tieulent, J. AU - Jemal, A. PY - 2015 DA - 2015// TI - Global cancer statistics, 2012 JO - CA Cancer J Clin VL - 65 UR - https://doi.org/10.3322/caac.21262 DO - 10.3322/caac.21262 ID - Torre2015 ER - TY - JOUR AU - Esposito, V. AU - Baldi, A. AU - Tonini, G. AU - Vincenzi, B. AU - Santini, M. AU - Ambrogi, V. AU - Mineo, T. C. AU - Persichetti, P. AU - Liuzzi, G. AU - Montesarchio, V. AU - Wolner, E. AU - Baldi, F. AU - Groeger, A. M. PY - 2004 DA - 2004// TI - Analysis of cell cycle regulator proteins in non-small cell lung cancer JO - J Clin Pathol VL - 57 UR - https://doi.org/10.1136/jcp.57.1.58 DO - 10.1136/jcp.57.1.58 ID - Esposito2004 ER - TY - JOUR AU - Eymin, B. AU - Gazzeri, S. PY - 2009 DA - 2009// TI - Role of cell cycle regulators in lung carcinogenesis JO - Cell Adhes Migrat. VL - 4 UR - https://doi.org/10.4161/cam.4.1.10977 DO - 10.4161/cam.4.1.10977 ID - Eymin2009 ER - TY - JOUR AU - Goel, S. AU - DeCristo, M. J. AU - McAllister, S. S. AU - Zhao, J. J. PY - 2018 DA - 2018// TI - CDK4/6 inhibition in cancer: beyond cell cycle arrest JO - Trends Cell Biol VL - 28 UR - https://doi.org/10.1016/j.tcb.2018.07.002 DO - 10.1016/j.tcb.2018.07.002 ID - Goel2018 ER - TY - JOUR AU - Klein, M. E. AU - Kovatcheva, M. AU - Davis, L. E. AU - Tap, W. D. AU - Koff, A. PY - 2018 DA - 2018// TI - CDK4/6 inhibitors: the mechanism of action may not be as simple as once thought JO - Cancer Cell VL - 34 UR - https://doi.org/10.1016/j.ccell.2018.03.023 DO - 10.1016/j.ccell.2018.03.023 ID - Klein2018 ER - TY - JOUR AU - Beaver, J. A. AU - Amiri-Kordestani, L. AU - Charlab, R. AU - Chen, W. AU - Palmby, T. AU - Tilley, A. PY - 2015 DA - 2015// TI - FDA approval: palbociclib for the treatment of postmenopausal patients with estrogen receptor-positive, HER2-negative metastatic breast cancer JO - Clin Cancer Res VL - 21 UR - https://doi.org/10.1158/1078-0432.CCR-15-1185 DO - 10.1158/1078-0432.CCR-15-1185 ID - Beaver2015 ER - TY - JOUR AU - Gopalan, P. K. AU - Villegas, A. G. AU - Cao, C. AU - Pinder-Schenck, M. AU - Chiappori, A. AU - Hou, W. PY - 2018 DA - 2018// TI - CDK4/6 inhibition stabilizes disease in patients with p16-null non-small cell lung cancer and is synergistic with mTOR inhibition JO - Oncotarget. VL - 9 UR - https://doi.org/10.18632/oncotarget.26424 DO - 10.18632/oncotarget.26424 ID - Gopalan2018 ER - TY - JOUR AU - Liu, M. AU - Xu, S. AU - Wang, Y. AU - Li, Y. AU - Li, Y. AU - Zhang, H. PY - 2016 DA - 2016// TI - PD 0332991, a selective cyclin D kinase 4/6 inhibitor, sensitizes lung cancer cells to treatment with epidermal growth factor receptor tyrosine kinase inhibitors JO - Oncotarget. VL - 7 UR - https://doi.org/10.18632/oncotarget.13069 DO - 10.18632/oncotarget.13069 ID - Liu2016 ER - TY - JOUR AU - Nie, H. AU - Zhou, X. AU - Shuzhang, D. AU - Nie, C. AU - Zhang, X. AU - Huang, J. PY - 2019 DA - 2019// TI - Palbociclib overcomes afatinib resistance in non-small cell lung cancer JO - Biomed Pharmacother VL - 109 UR - https://doi.org/10.1016/j.biopha.2018.10.170 DO - 10.1016/j.biopha.2018.10.170 ID - Nie2019 ER - TY - JOUR AU - Pacheco, J. AU - Schenk, E. PY - 2019 DA - 2019// TI - CDK4/6 inhibition alone and in combination for non-small cell lung cancer JO - Oncotarget. VL - 10 UR - https://doi.org/10.18632/oncotarget.26545 DO - 10.18632/oncotarget.26545 ID - Pacheco2019 ER - TY - JOUR AU - Zhou, J. AU - Zhang, S. AU - Chen, X. AU - Zheng, X. AU - Yao, Y. AU - Lu, G. PY - 2017 DA - 2017// TI - Palbociclib, a selective CDK4/6 inhibitor, enhances the effect of selumetinib in RAS-driven non-small cell lung cancer JO - Cancer Lett VL - 408 UR - https://doi.org/10.1016/j.canlet.2017.08.031 DO - 10.1016/j.canlet.2017.08.031 ID - Zhou2017 ER - TY - JOUR AU - Franco, J. AU - Balaji, U. AU - Freinkman, E. AU - Witkiewicz, A. K. AU - Knudsen, E. S. PY - 2016 DA - 2016// TI - Metabolic reprogramming of pancreatic cancer mediated by CDK4/6 inhibition elicits unique vulnerabilities JO - Cell Rep. VL - 14 UR - https://doi.org/10.1016/j.celrep.2015.12.094 DO - 10.1016/j.celrep.2015.12.094 ID - Franco2016 ER - TY - JOUR AU - Tarrado-Castellarnau, M. AU - Atauri, P. AU - Tarrago-Celada, J. AU - Perarnau, J. AU - Yuneva, M. AU - Thomson, T. M. PY - 2017 DA - 2017// TI - De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition JO - Mol Syst Biol. VL - 13 UR - https://doi.org/10.15252/msb.20167321 DO - 10.15252/msb.20167321 ID - Tarrado-Castellarnau2017 ER - TY - JOUR AU - Wang, H. AU - Nicolay, B. N. AU - Chick, J. M. AU - Gao, X. AU - Geng, Y. AU - Ren, H. PY - 2017 DA - 2017// TI - The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival JO - Nature VL - 546 UR - https://doi.org/10.1038/nature22797 DO - 10.1038/nature22797 ID - Wang2017 ER - TY - JOUR AU - Klavins, K. AU - Drexler, H. AU - Hann, S. AU - Koellensperger, G. PY - 2014 DA - 2014// TI - Quantitative metabolite profiling utilizing parallel column analysis for simultaneous reversed-phase and hydrophilic interaction liquid chromatography separations combined with tandem mass spectrometry JO - Anal Chem VL - 86 UR - https://doi.org/10.1021/ac5003454 DO - 10.1021/ac5003454 ID - Klavins2014 ER - TY - JOUR AU - Adusumilli, R. AU - Mallick, P. PY - 2017 DA - 2017// TI - Data conversion with ProteoWizard msConvert JO - Methods Mol Biol VL - 1550 UR - https://doi.org/10.1007/978-1-4939-6747-6_23 DO - 10.1007/978-1-4939-6747-6_23 ID - Adusumilli2017 ER - TY - CHAP AU - Agrawal, S. AU - Kumar, S. AU - Sehgal, R. AU - George, S. AU - Gupta, R. AU - Poddar, S. ED - D’Alessandro, A. PY - 2019 DA - 2019// TI - El-MAVEN: a fast, robust, and user-friendly mass spectrometry data processing engine for metabolomics BT - High-throughput metabolomics: methods and protocols PB - Springer CY - New York ID - Agrawal2019 ER - TY - JOUR AU - Salabei, J. K. AU - Lorkiewicz, P. K. AU - Mehra, P. AU - Gibb, A. A. AU - Haberzettl, P. AU - Hong, K. U. PY - 2016 DA - 2016// TI - Type 2 diabetes dysregulates glucose metabolism in cardiac progenitor Cells JO - J Biol Chem VL - 291 UR - https://doi.org/10.1074/jbc.M116.722496 DO - 10.1074/jbc.M116.722496 ID - Salabei2016 ER - TY - JOUR AU - Wei, X. AU - Lorkiewicz, P. K. AU - Shi, B. AU - Salabei, J. K. AU - Hill, B. G. AU - Kim, S. PY - 2017 DA - 2017// TI - Analysis of stable isotope assisted metabolomics data acquired by high resolution mass spectrometry JO - Anal Methods VL - 9 UR - https://doi.org/10.1039/C7AY00291B DO - 10.1039/C7AY00291B ID - Wei2017 ER - TY - JOUR AU - Lorkiewicz, P. K. AU - Gibb, A. A. AU - Rood, B. R. AU - He, L. AU - Zheng, Y. AU - Clem, B. F. PY - 2019 DA - 2019// TI - Integration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretation JO - Scientific Reports. VL - 9 UR - https://doi.org/10.1038/s41598-019-50183-3 DO - 10.1038/s41598-019-50183-3 ID - Lorkiewicz2019 ER - TY - JOUR AU - Cretella, D. AU - Fumarola, C. AU - Bonelli, M. AU - Alfieri, R. AU - Monica, S. AU - Digiacomo, G. PY - 2019 DA - 2019// TI - Pre-treatment with the CDK4/6 inhibitor palbociclib improves the efficacy of paclitaxel in TNBC cells JO - Sci Rep. VL - 9 UR - https://doi.org/10.1038/s41598-019-49484-4 DO - 10.1038/s41598-019-49484-4 ID - Cretella2019 ER - TY - JOUR AU - Cretella, D. AU - Ravelli, A. AU - Fumarola, C. AU - Monica, S. AU - Digiacomo, G. AU - Cavazzoni, A. PY - 2018 DA - 2018// TI - The anti-tumor efficacy of CDK4/6 inhibition is enhanced by the combination with PI3K/AKT/mTOR inhibitors through impairment of glucose metabolism in TNBC cells JO - J Exp Clin Cancer Res. VL - 37 UR - https://doi.org/10.1186/s13046-018-0741-3 DO - 10.1186/s13046-018-0741-3 ID - Cretella2018 ER - TY - JOUR AU - Knudsen, E. S. AU - Witkiewicz, A. K. PY - 2016 DA - 2016// TI - Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2− breast cancer JO - Oncotarget. VL - 7 UR - https://doi.org/10.18632/oncotarget.11588 DO - 10.18632/oncotarget.11588 ID - Knudsen2016 ER - TY - JOUR AU - Daye, D. AU - Wellen, K. E. PY - 2012 DA - 2012// TI - Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis JO - Semin Cell Dev Biol VL - 23 UR - https://doi.org/10.1016/j.semcdb.2012.02.002 DO - 10.1016/j.semcdb.2012.02.002 ID - Daye2012 ER - TY - JOUR AU - DeBerardinis, R. J. AU - Cheng, T. PY - 2010 DA - 2010// TI - Q’s next: the diverse functions of glutamine in metabolism, cell biology and cancer JO - Oncogene VL - 29 UR - https://doi.org/10.1038/onc.2009.358 DO - 10.1038/onc.2009.358 ID - DeBerardinis2010 ER - TY - JOUR AU - DeBerardinis, R. J. AU - Mancuso, A. AU - Daikhin, E. AU - Nissim, I. AU - Yudkoff, M. AU - Wehrli, S. PY - 2007 DA - 2007// TI - Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis JO - Proc Natl Acad Sci USA VL - 104 UR - https://doi.org/10.1073/pnas.0709747104 DO - 10.1073/pnas.0709747104 ID - DeBerardinis2007 ER - TY - JOUR AU - Boysen, G. AU - Jamshidi-Parsian, A. AU - Davis, M. A. AU - Siegel, E. R. AU - Simecka, C. M. AU - Kore, R. A. PY - 2019 DA - 2019// TI - Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice JO - Int J Radiat Biol VL - 95 UR - https://doi.org/10.1080/09553002.2018.1558299 DO - 10.1080/09553002.2018.1558299 ID - Boysen2019 ER - TY - JOUR AU - Cairns, R. A. AU - Harris, I. S. AU - Mak, T. W. PY - 2011 DA - 2011// TI - Regulation of cancer cell metabolism JO - Nat Rev Cancer VL - 11 UR - https://doi.org/10.1038/nrc2981 DO - 10.1038/nrc2981 ID - Cairns2011 ER - TY - JOUR AU - DeBerardinis, R. J. AU - Chandel, N. S. PY - 2016 DA - 2016// TI - Fundamentals of cancer metabolism JO - Sci Adv. VL - 2 UR - https://doi.org/10.1126/sciadv.1600200 DO - 10.1126/sciadv.1600200 ID - DeBerardinis2016 ER - TY - JOUR AU - DeBerardinis, R. J. AU - Lum, J. J. AU - Hatzivassiliou, G. AU - Thompson, C. B. PY - 2008 DA - 2008// TI - The biology of cancer: metabolic reprogramming fuels cell growth and proliferation JO - Cell Metab VL - 7 UR - https://doi.org/10.1016/j.cmet.2007.10.002 DO - 10.1016/j.cmet.2007.10.002 ID - DeBerardinis2008 ER - TY - JOUR AU - Martinez-Outschoorn, U. E. AU - Peiris-Pages, M. AU - Pestell, R. G. AU - Sotgia, F. AU - Lisanti, M. P. PY - 2017 DA - 2017// TI - Cancer metabolism: a therapeutic perspective JO - Nat Rev Clin Oncol. VL - 14 UR - https://doi.org/10.1038/nrclinonc.2016.60 DO - 10.1038/nrclinonc.2016.60 ID - Martinez-Outschoorn2017 ER - TY - JOUR AU - Pavlova, N. N. AU - Thompson, C. B. PY - 2016 DA - 2016// TI - The emerging hallmarks of cancer metabolism JO - Cell Metab VL - 23 UR - https://doi.org/10.1016/j.cmet.2015.12.006 DO - 10.1016/j.cmet.2015.12.006 ID - Pavlova2016 ER - TY - JOUR AU - Blanchet, E. AU - Annicotte, J. S. AU - Lagarrigue, S. AU - Aguilar, V. AU - Clape, C. AU - Chavey, C. PY - 2011 DA - 2011// TI - E2F transcription factor-1 regulates oxidative metabolism JO - Nat Cell Biol VL - 13 UR - https://doi.org/10.1038/ncb2309 DO - 10.1038/ncb2309 ID - Blanchet2011 ER - TY - JOUR AU - Bonelli, M. AU - Monica, S. AU - Fumarola, C. AU - Alfieri, R. PY - 2019 DA - 2019// TI - Multiple effects of CDK4/6 inhibition in cancer: from cell cycle arrest to immunomodulation JO - Biochem Pharmacol VL - 170 UR - https://doi.org/10.1016/j.bcp.2019.113676 DO - 10.1016/j.bcp.2019.113676 ID - Bonelli2019 ER - TY - JOUR AU - Burkhart, D. L. AU - Sage, J. PY - 2008 DA - 2008// TI - Cellular mechanisms of tumour suppression by the retinoblastoma gene JO - Nat Rev Cancer VL - 8 UR - https://doi.org/10.1038/nrc2399 DO - 10.1038/nrc2399 ID - Burkhart2008 ER - TY - JOUR AU - Clem, B. F. AU - Chesney, J. PY - 2012 DA - 2012// TI - Molecular pathways: regulation of metabolism by RB JO - Clin Cancer Res VL - 18 UR - https://doi.org/10.1158/1078-0432.CCR-11-3164 DO - 10.1158/1078-0432.CCR-11-3164 ID - Clem2012 ER - TY - JOUR AU - Gao, P. AU - Tchernyshyov, I. AU - Chang, T. C. AU - Lee, Y. S. AU - Kita, K. AU - Ochi, T. PY - 2009 DA - 2009// TI - c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism JO - Nature VL - 458 UR - https://doi.org/10.1038/nature07823 DO - 10.1038/nature07823 ID - Gao2009 ER - TY - JOUR AU - Goetzman, E. S. AU - Prochownik, E. V. PY - 2018 DA - 2018// TI - The role for Myc in coordinating glycolysis, oxidative phosphorylation, glutaminolysis, and fatty acid metabolism in normal and neoplastic tissues JO - Front Endocrinol VL - 9 UR - https://doi.org/10.3389/fendo.2018.00129 DO - 10.3389/fendo.2018.00129 ID - Goetzman2018 ER - TY - JOUR AU - Takebayashi, S. AU - Tanaka, H. AU - Hino, S. AU - Nakatsu, Y. AU - Igata, T. AU - Sakamoto, A. PY - 2015 DA - 2015// TI - Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells JO - Aging Cell VL - 14 UR - https://doi.org/10.1111/acel.12351 DO - 10.1111/acel.12351 ID - Takebayashi2015 ER - TY - JOUR AU - Thangavel, C. AU - Boopathi, E. AU - Liu, Y. AU - McNair, C. AU - Haber, A. AU - Perepelyuk, M. PY - 2018 DA - 2018// TI - Therapeutic challenge with a CDK 4/6 inhibitor induces an RB-dependent SMAC-mediated apoptotic response in non-small cell lung cancer JO - Clin Cancer Res VL - 24 UR - https://doi.org/10.1158/1078-0432.CCR-17-2074 DO - 10.1158/1078-0432.CCR-17-2074 ID - Thangavel2018 ER - TY - JOUR AU - Vijayaraghavan, S. AU - Karakas, C. AU - Doostan, I. AU - Chen, X. AU - Bui, T. AU - Yi, M. PY - 2017 DA - 2017// TI - CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers JO - Nat Commun. VL - 8 UR - https://doi.org/10.1038/ncomms15916 DO - 10.1038/ncomms15916 ID - Vijayaraghavan2017 ER - TY - JOUR AU - Kwon, S. M. AU - Hong, S. M. AU - Lee, Y. K. AU - Min, S. AU - Yoon, G. PY - 2019 DA - 2019// TI - Metabolic features and regulation in cell senescence JO - BMB Rep. VL - 52 UR - https://doi.org/10.5483/BMBRep.2019.52.1.291 DO - 10.5483/BMBRep.2019.52.1.291 ID - Kwon2019 ER - TY - JOUR AU - Salama, R. AU - Sadaie, M. AU - Hoare, M. AU - Narita, M. PY - 2014 DA - 2014// TI - Cellular senescence and its effector programs JO - Genes Dev VL - 28 UR - https://doi.org/10.1101/gad.235184.113 DO - 10.1101/gad.235184.113 ID - Salama2014 ER - TY - JOUR AU - Rabinowitz, J. D. AU - White, E. PY - 2010 DA - 2010// TI - Autophagy and metabolism JO - Science VL - 330 UR - https://doi.org/10.1126/science.1193497 DO - 10.1126/science.1193497 ID - Rabinowitz2010 ER -