Fig. 4
From: Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells
Palbociclib increases mitochondrial respiration in A549 cells. a Oxygen consumption rate (OCR) measured in A549 cells following knockdown of RB and 48-h treatment with 1 μM palbociclib. b–g OCR assessment of b basal respiration, c non-mitochondrial respiration, d maximal respiration, e ATP production, f proton leak, and g spare capacity. Values represent mean ± SD, analyzed by two-way ANOVA (n = 3, independent experiments). Statistical significances between vehicle and palbociclib treatment are as follows: *p = 0.034, **p = 0.01, and ***p = 0.002