Fig. 1

Circular RNA circOSBPL10 was highly expressed in CC and knockdown of it suppressed CC progression. a CircOSBPL10 expression was detected by RT-qPCR in CC cell lines H8 cells. b It was delineated by nucleic acid electrophoresis analysis that divergent primers amplified circOSBPL10 from cDNA, but not from gDNA. GAPDH was a negative control. c The resistance of circOSBPL10 and OSBPL10 mRNA to ActD in SiHa and HeLa cells was analyzed by RT-qPCR. d RT-qPCR assay was conducted to determine the abundance of circOSBPL10 and linear OSBPL10 mRNA in SiHa and HeLa cells treated with RNase R (normalized to mock treatment). e RT-qPCR was utilized to analyze the efficacy of circOSBPL10 knockdown in SiHa and HeLa cells. f, g The proliferation ability of SiHa and HeLa cells transfected with sh-circOSBPL10#1 or sh-NC was evaluated via CCK-8 and colony formation. h, i Cell apoptosis ability in transfected cells was measured by TUNEL assay and flow cytometry analysis. j, k Transwell and wound healing assays were conducted to analyze the migration of transfected cells. *P < 0.05, **P < 0.01